OPEN BAR: Top 10 things millenials hate about OB that we didn't know last week!

[Reginald Ret]

This is dumber than homeopathy.
Wait:
first hit on a reputable source, namely pubmed: "Histamine intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation. Histamine is a biogenic amine that occurs to various degrees in many foods. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity."

Wait some more:
more than 500 hits on google scholar not counting citations and patents.
First one from 1983.

True, it is not a lot, but it seems to be taken seriously by people who are very good at the biochem techno-babble.

Example:

Histamine can be metabolized by two pathways:
- oxidative deamination via diamino oxidase (DAO) (formerly known as histaminease)
- ring methylation via histamine-N-methyl transferase (HNMT)

DAO is a secretory protein responsible for the breakdown of extra cellular histamine,
whereas HNMT, a cytosolic protein, inactivates histamine only intracellularly, for example
in the liver (2). The enzyme DAO therefore plays a key role in the breakdown of dietary
histamine. Insufficient DAO activity can thus lead to the symptoms described, e.g., after
ingestion of histamine rich foods, (5), alcohol (6) or histamine liberating or DAO blocking
medications (7).
Various possible mechanisms have been discussed as the cause of histamine intolerance
(1). The production of DAO may for example be reduced by damage to enterocytes in
gastrointestinal disease (11, 21). Other biogenic amines, alcohol (18) and medications
(7, 19) can also competitively inhibit the breakdown of histamine by DAO. Acquired
histamine intolerance may be reversible where the cause if removed, such as the dis-
continuation of DAO blocking medications.

Note: minor editing in quote because copypasta didn't work properly.

Yes, deficiencies in breaking down histamine is a real, biological occurrence. Just like deficiencies in breaking down gluten and deficiencies in breaking down lactose. That means there's just enough science behind a very rare enzyme pathway deficiency to make the health quack crowd BILLIONS when they convince millions of Americans that they, too, have a histamine intolerance.

Yep, but learning that did change my mind about one thing: Now I think homeopathy is dumber.

[Cain]

Portland: Today someone said "I know people who can't do bone broth because they have histamine intolerance".

Alone amongst the crowd, I am utterly unshocked by this.

Full of hate, but unshocked.

Betcha that 99% of these "histamine intolerant" people drink wine. Because the histamines in wine don't count.

Wine is calorie, carb, sugar, completely chemical-free goodness.  Everyone knows that.

Only red wine though.

And only brands that nobody's ever heard of, that you have to order special.

Naturally.  The more obscure they are, the more they are filled with "good histamines".  These are like good bacteria, which your body needs to function normally

[Trivial]

#BobbyJindalissowhite on twitter 

Also I learned things.

[Mesozoic Mister Nigel]

Portland: Today someone said "I know people who can't do bone broth because they have histamine intolerance".

Alone amongst the crowd, I am utterly unshocked by this.

Full of hate, but unshocked.

Betcha that 99% of these "histamine intolerant" people drink wine. Because the histamines in wine don't count.

Wine is calorie, carb, sugar, completely chemical-free goodness.  Everyone knows that.

Only red wine though.

And only brands that nobody's ever heard of, that you have to order special.

Organic, of course. And gluten-free.

[Mesozoic Mister Nigel]

This is dumber than homeopathy.
Wait:
first hit on a reputable source, namely pubmed: "Histamine intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation. Histamine is a biogenic amine that occurs to various degrees in many foods. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity."

Wait some more:
more than 500 hits on google scholar not counting citations and patents.
First one from 1983.

True, it is not a lot, but it seems to be taken seriously by people who are very good at the biochem techno-babble.

Example:

Histamine can be metabolized by two pathways:
- oxidative deamination via diamino oxidase (DAO) (formerly known as histaminease)
- ring methylation via histamine-N-methyl transferase (HNMT)

DAO is a secretory protein responsible for the breakdown of extra cellular histamine,
whereas HNMT, a cytosolic protein, inactivates histamine only intracellularly, for example
in the liver (2). The enzyme DAO therefore plays a key role in the breakdown of dietary
histamine. Insufficient DAO activity can thus lead to the symptoms described, e.g., after
ingestion of histamine rich foods, (5), alcohol (6) or histamine liberating or DAO blocking
medications (7).
Various possible mechanisms have been discussed as the cause of histamine intolerance
(1). The production of DAO may for example be reduced by damage to enterocytes in
gastrointestinal disease (11, 21). Other biogenic amines, alcohol (18) and medications
(7, 19) can also competitively inhibit the breakdown of histamine by DAO. Acquired
histamine intolerance may be reversible where the cause if removed, such as the dis-
continuation of DAO blocking medications.

Note: minor editing in quote because copypasta didn't work properly.

Yes, deficiencies in breaking down histamine is a real, biological occurrence. Just like deficiencies in breaking down gluten and deficiencies in breaking down lactose. That means there's just enough science behind a very rare enzyme pathway deficiency to make the health quack crowd BILLIONS when they convince millions of Americans that they, too, have a histamine intolerance.

Yep, but learning that did change my mind about one thing: Now I think homeopathy is dumber.

That it is. Oh yes,  that it is.

[Mesozoic Mister Nigel]

Portland: Today someone said "I know people who can't do bone broth because they have histamine intolerance".

Alone amongst the crowd, I am utterly unshocked by this.

Full of hate, but unshocked.

Betcha that 99% of these "histamine intolerant" people drink wine. Because the histamines in wine don't count.

Wine is calorie, carb, sugar, completely chemical-free goodness.  Everyone knows that.

Only red wine though.

And only brands that nobody's ever heard of, that you have to order special.

Naturally.  The more obscure they are, the more they are filled with "good histamines".  These are like good bacteria, which your body needs to function normally

[Doktor Howl]

We should make this a thing. They'd go for it, if we present it properly.

[Mesozoic Mister Nigel]

We should make this a thing. They'd go for it, if we present it properly.

It's a good thing they're inverted! 

[Doktor Howl]

I prefer the term "pre-prolapsed".

[Cain]

At least they're boneless.  Nothing worse than a boney, inverted rectum.

[Mesozoic Mister Nigel]

 Both of you.

[LMNO]

Soon to be known as "Pork Calamari".

[Mesozoic Mister Nigel]

Soon to be known as "Pork Calamari".

Ah, the stuff of urban legends.

[LMNO]

Did you see the piece on NPR that put it to a blind taste test?  It was really interesting.  The takeaway was that, if washed well enough first, it basically really does taste like a tough piece of calamari.

The magic of deep frying!

[Mesozoic Mister Nigel]

Did you see the piece on NPR that put it to a blind taste test?  It was really interesting.  The takeaway was that, if washed well enough first, it basically really does taste like a tough piece of calamari.

The magic of deep frying!

Yeah... they basically went in search of the rumor that it was actually being served as calamari in restaurants, and when they were unable to find any evidence for that, they went with "but COULD it hypothetically be served as calamari?" and then concluded that if it were "prepared properly" they could see it being passed off for calamari.

I was like, really NPR?