Show Posts

This section allows you to view all posts made by this member. Note that you can only see posts made in areas you currently have access to.


Messages - PoFP

Pages: [1] 2 3 4 ... 60
1
Apple Talk / Re: Open Bar: Free Russian Orphans with Every Purchase
« on: April 17, 2018, 05:21:16 pm »
Friend of a friend was in some PTSD study that involved MDMA.

I had never considered that one, but it does also appear to have Sigma Receptor activity. Specifically, it appears to over-activate Sigma-1 Receptors at recreational doses (In that reversing this action seems to decrease the drug's side effects), meaning it would likely activate them at realistic levels at the therapeutic (lower) dose. I'm definitely thinking some sort of interplay between Sigma-1 receptor agonism and increases in monoamine transmission (Dopamine, Serotonin, etc.) are the main causes for the therapeutic effects of these drugs at this point. I suspect a combination of Dextromethorphan and small amounts of Hyperforin (Found in St. John's Wart) might be adequate OTC treatments for both PTSD and Depression. Only small amounts of the Hyperforin would be recommended, as too much Serotonin transmission causes Serotonin Syndrome.

Hopefully the MDMA and Ketamine trials work out as well, as they would likely be stronger treatments when combined with the usual therapy.

2
Apple Talk / Re: Open Bar: Free Russian Orphans with Every Purchase
« on: April 17, 2018, 03:15:32 pm »
As far as I know, they are actually making some headway with Ketamine on both Depressive/Mood disorders and PTSD. Granted, they are still in the Trial stage at the moment (So I guess you could say it's still "try shit and see if it works.") but it looks quite promising. The known effects of Ketamine don't seem to fit with the effects it's having on these disorders (In that drugs with identical or similar known mechanisms - NMDA Receptor Antagonism - aren't as successful), but once they figure out what mechanism is treating them, it might open up a whole new target for treatment, and may give new insight into the low-level pathology of the disorders.

Personally, I suspect it has a lot to do with the neural activity-stabilization and neuro-protective effects of the Sigma receptors. It's never been tried before (Likely because of its abuse patterns), but I suspect that Dextromethorphan (Polistirex-binded, not HBr), which has similar known effects to Ketamine (NMDA Receptor Antagonism and Sigma Receptor Agonism), could be helpful in treating PTSD as well. It would also have the added benefit of acting on Serotonin (Although, not selectively like most anti-depressants) to treat comorbid depressive symptoms.

3
Apple Talk / Re: Open Bar: Free Russian Orphans with Every Purchase
« on: April 16, 2018, 09:12:30 pm »
Also also, I wasn't implying that you were dissatisfied with your psychologist. I was just emphasizing the importance of the dosage in its effects, as the effects become completely opposing to what is expected depending on the dose (Seemed to be what you were experiencing, but if you insist this was false, then it probably was, and I apologize for that, too.).

For instance, I seem to be radically resistant to almost all medications despite my normal weight. So in most cases, a normal dose for one person may quite literally have the opposite effects on me, whereas an increase in my dosage to sometimes double would have the intended effects. This isn't really something psychiatrists always take into account, at least not until they become aware of it for the individual they're prescribing for.

4
Apple Talk / Re: Open Bar: Free Russian Orphans with Every Purchase
« on: April 16, 2018, 09:08:19 pm »
Also, it's  very likely that a) I have PTSD, 2) it had it before I joined the army, and c) the army made it worse. And this might explain why half of my BP isn't  fully responding to my meds and why I had an extremely atypical reaction to another.

This is possible, but speaking from experience, I wouldn't rule out a physiological problem.

That is likely. Seroquel should not have made me react in almost the opposite of its function. But I think the PTSD is likely why Lamictal isn't doing much for my manic irritability while helping with the depression.

Lamictal is actually known for mainly treating the depressive phase of BP, not so much the manic phase. Specifically, it should decrease the amplitude of the low, and delay the high, but it usually won't prevent it or dampen it.

The Seroquel activity depends on genetic predisposition to favoring certain neurotransmitter activity over another, and also depends on dosage. You may wanna discuss dosage of that one with your doctor, as you may need more or less. If they're not aware of that distinction, or think it irrelevant, you may wanna shop around for another doctor if possible.

I appreciate the concern and I know that it's where your info dump and advice come from, which is why I'm not going in a tear about the implied insult that I am so dumb i would not have done research into my health or the medications I am on and my treatment. I am well aware what lamotrigine primarily treats in bp. I am week aware of what quetiapine is and does. BPII and PTSD are treated in different ways with different kinds of drugs and therapy. My treatmenttement needs to be adjusted in light of the new revelation. And before you point out that one of the unapproved uses for lamotrigine is top treat PTSD, it its clearly not currently working fully.

I will however point out that were I dissatisfied with my psychologist or the staff psychiatrist I would be venting about that and not talking about my experiences in the joy that is trying out psychiatric drugs.

I apologize for anything that may have seemed to be implied by what I said. I sometimes come across as mansplainy and arrogant at times, and I am working on it (It likely stems from the fact that my job is based on explaining and diagnosing problems for people of various levels of education, forcing me to find a low compromise in vocabulary and explanation detail most of the time.). I just wanted to explain my perspective on your situation based on the biochemical and pharmacological knowledge I've gained from my extensive studies of those subjects in general. I also didn't want to get into a bunch of chemical/medical jargon, so I simplified it quite a bit. I did not mean for it to imply that you knew less about the medication than I did. If anything, it was aimed more at triggering a detailed discussion that would increase my knowledge.

Also, I certainly didn't mean to say that you should stop either of the medications you were referring to. It's completely understandable that you wanted to change medications or dosage, even though the combination would normally be expected to work. Obviously if you are still having issues, something is wrong with the medication/dosage/interaction with your genetic predispositions.

Also also, I wasn't implying that you were dissatisfied with your psychologist. I was just emphasizing the importance of the dosage in its effects, as the effects become completely opposing to what is expected depending on the dose (Seemed to be what you were experiencing, but if you insist this was false, then it probably was, and I apologize for that, too.).

5
Apple Talk / Re: Open Bar: Free Russian Orphans with Every Purchase
« on: April 16, 2018, 02:54:10 pm »
Also, it's  very likely that a) I have PTSD, 2) it had it before I joined the army, and c) the army made it worse. And this might explain why half of my BP isn't  fully responding to my meds and why I had an extremely atypical reaction to another.

This is possible, but speaking from experience, I wouldn't rule out a physiological problem.

That is likely. Seroquel should not have made me react in almost the opposite of its function. But I think the PTSD is likely why Lamictal isn't doing much for my manic irritability while helping with the depression.

Lamictal is actually known for mainly treating the depressive phase of BP, not so much the manic phase. Specifically, it should decrease the amplitude of the low, and delay the high, but it usually won't prevent it or dampen it.

The Seroquel activity depends on genetic predisposition to favoring certain neurotransmitter activity over another, and also depends on dosage. You may wanna discuss dosage of that one with your doctor, as you may need more or less. If they're not aware of that distinction, or think it irrelevant, you may wanna shop around for another doctor if possible.

6
Or Kill Me / Re: The left and the right
« on: April 16, 2018, 01:54:27 pm »
I honestly can't tell if he's a self-loathing masochist who requires negative attention, or if he's just so attention-starved and socially retarded that he takes whatever attention he can get. He seems to stick around, regardless of how many times we tell him how horrible he is (And he hasn't improved in the slightest over the years.), so I can only assume it's the former. Usually, even attention-starved morons can only take so many beatings.

"Mystery Man: In the East, the Far East, when a person is sentenced to death
 they're sent to a place where they can't escape, never knowing when..."

I just felt like saying that, because I'm a badass motherfucker, so I walk and talk this way.

I don't know why, but I laughed for a good 5 minutes at this.  :lulz:

7
Or Kill Me / Re: The left and the right
« on: April 10, 2018, 02:56:35 pm »
I honestly can't tell if he's a self-loathing masochist who requires negative attention, or if he's just so attention-starved and socially retarded that he takes whatever attention he can get. He seems to stick around, regardless of how many times we tell him how horrible he is (And he hasn't improved in the slightest over the years.), so I can only assume it's the former. Usually, even attention-starved morons can only take so many beatings.

8
Bring and Brag / Re: P3nT's Shoops
« on: April 06, 2018, 06:20:23 pm »
^^^ Seconded

These are amazing. The longer I look at these, the more details make themselves known.

9
Apple Talk / Re: Open Bar: Free Russian Orphans with Every Purchase
« on: March 13, 2018, 12:38:28 pm »
Didn't know where to put this so http://HonestBobsUsedDildoEmporium.co​m

I was honestly surprised.

Same here. I didn't expect it to actually lead to a gallery of previously unwanted dildos.

10
Apple Talk / Re: Open Bar: Free Russian Orphans with Every Purchase
« on: March 05, 2018, 04:00:53 pm »
Had another blood test and his platelets are almost normal.  His IgM levels are damn high though. 

dunno wtf is going on

Damn, sorry to hear :(

They thinking HIGM? Or some kind of infection/Immune overreaction?

11
Techmology and Scientism / Re: ⯰
« on: February 21, 2018, 01:55:33 pm »
Hey spags! Have a (possible?) future Hand of Eris symbol:


a rectangle? seems kinda square

Ahaaauuuuuuuuaaauauuua, yesssss  :golfclap:

12
Apple Talk / Re: Open Bar: Free Russian Orphans with Every Purchase
« on: February 20, 2018, 04:47:26 pm »
Glad you and Don are okay/alive!



Came into the office today to learn that our IT department decided to block network access to several of our team's necessary web applications (And Facebook!  :argh!: ). The last time they did this, they did it by blocking access to some applications on only our system-wide proxy, and blocking other applications on the DIRECT connection, which was easily bypassed with a simple modification to our proxy script. But now they've blocked all kinds of shit on BOTH the proxy and DIRECT connection.

If someone had told me that I was gonna have to solve riddles in order to perform my required job functions, I would've joined Nicholas Cage as a Treasure Hunter.

Also, it's shit like this that makes security breaches like those that made our executives have a couple heart attacks last week well-deserved.

I'm so glad the company I'm supporting via contract is interested in my skills. My company obviously doesn't give a shit.

13
Think for Yourself, Schmuck! / Re: Reality Safari: Gurdjieff
« on: February 19, 2018, 06:17:00 pm »
In our group, we've been talking about the Black Iron Prison. (They don't use the "black iron" part, but it's defintiely the same idea.)

Our automatism takes over our lives. We need habits and schemas and heuristics, but we get stuck in them like machines.

Through dilligent and continual self-observation, we can develop an internal "watcher" who can notice when we have slipped into our mechanical routines.

When you notice yourself acting mechanically, that in itself is a type of freedom (or a sign post pointing towards it). When you observe the Robot, the part of you making the observation is not the Robot. If only we could remember that part of ourselves all the time...


There are practical things you can do, physically, which help you develop this watcher. The body and mind and emotions are tightly linked. Your postures and habits always seem to lead you back to your normal automatic way of being. You might try to be different from how you are today, but then you fall into a habit (smoking a cigarette, answering the phone, whatever) and suddenly the Robot is driving again. So maybe there are postures and movements which the robot cannot do. If we experiment with them, perhaps we can find a new way of thinking, feeling, being.

This got me thinking about the behavioral tendencies of those who always seem to counter the status quo and the natural order of things, and how they connect to the brain.

I'm sure we all remember that kid from grade-school that wouldn't keep still. He/she's always rocking back and forth in their chair, tapping their feet, tapping their pencil on the desk, tilting the desk back and forth, etc. They were often clumsy, and would occasionally tilt their chair back too far and eat shit in front of the whole class. And on the other end of the spectrum, we all remember that person who was almost pathologically consistent and precise with their movements. They didn't move unless they had to, and when they did, they tried to make sure it was quiet and unnoticeable. Each action was often completely calculated.

These behavioral tendencies represent the opposing sides of the awareness/consciousness scale from a neurological standpoint.

The kid who can't stop moving is often described as the kid with ADHD. More complex disorder symptom presentations exist, of course, but for the sake of simplicity and concision, this will suffice.

The kid who calculates all of their decisions and movements could potentially have some sort of OCD or anxiety disorder.

Each of these disorders is involved with the relationship between the Basal Ganglia, which is an important set of brain structures that are essential for the Reward Center of the brain, and the Prefrontal Cortex, which is responsible for establishment of memory, as well as conscious awareness and lucidity. It's theorized that focus and attention manifest as a result of a reverberating feedback loop between these two brain structures, and that dysfunction of this circuit results in disorders like those described above.

When the Basal Ganglia is active, but requires higher-order processing for executive function, it triggers activation of the Prefrontal Cortex. Here, information is processed and stored for later retrieval in the form of consequence cognition, and other information required for conscious decision-making. When the prefrontal cortex is finished, it sends a "cool, message received and handled, now fuck off" message back to the Basal Ganglia, reducing its overall activity to prepare it for the firing it will need to re-activate the prefrontal cortex in the future. For the kid with ADHD, this relationship is weak. The Basal Ganglia's signals aren't strong enough to trigger or maintain activation of the prefrontal cortex effectively, reducing the amount of information that is stored for executive functioning and memory, and reducing the person's overall awareness. The brain, which requires this relationship's success to function properly, craves dopaminergic release in the Basal Ganglia to strengthen the bond between the two structures, since they mainly communicate with Dopaminergic circuits. This is achieved with self-medication using stimulants, or with the excess physical activity we've been observing, since motor control in the brain is also regulated largely with Dopamine. This habitual, excessive physical activity acts as an anchor for consciousness and awareness, and demonstrates precisely what you were describing above. Without it, the ADHDer remains a slave to habitual monotony.

The person with calculated decisions has the exact opposite problem. Their Basal Ganglia is suppressed by excessive activation of the prefrontal cortex, and that "fuck off" message that gets sent as a response. They lack the ability to form the habits that allow them to go on autopilot, placing them in a state of constant awareness. Minor details, like their movements and physical actions, get hyper-analyzed and the person loses the ability to naturally focus on the important details in their current situation. The mind's reaction to this is the ability to multitask constantly, which overloads and exhausts the person, leaving them unwilling to go out of their comfort zone.

Most people who don't have pathologies are somewhere in between these two points on the awareness scale in terms of behavior and cognition. Developing a method for intentional, and productive (As opposed to habitual) awareness should likely be based on the neurological circuit behavior of the person who intends to change. For the person who is often too aware, the solution may be scheduling a simple set of actions to take regularly (Either every day, or every couple hours) that require little effort and attention, to allow for the prefrontal cortex to take a break from processing menial tasks once the scheduled task has become habitual. Otherwise, it may be applicable to take a GABA-A receptor agonist, like Valerian Root in order to calm the prefrontal cortex and allow for productive awareness when it's intended, and not at all times.

For the person who is often less aware, the solution could require stimulants to fix the imbalance, or similar actions to the ones you've described previously regarding leaving yourself triggers for momentary consciousness. It could also be assisted with the ADHDer's natural supplement: Excessive physical activity. Make it a point to tap your fingers or feet on something to anchor yourself to your surroundings and environment and trigger awareness. But be sure to avoid consistent timing and activity patterns, so as to prevent it from becoming a habit. As you mentioned before, the moment you perform something habitual, you put yourself at risk of losing your awareness.


I'm reading this James Moore biography of Gurdjieff. He keeps invoking this image of the Yazidi children who Gurdjieff played with when he was growing up. The Yazidi are thought of as devil worshippers. If you draw a circle of salt around a Yazidi, they won't be able to get out of it.

Gurdjieff's role as a teacher was to disturb the circle of salt that people draw around themselves.

For example, the Hartmanns came from an upper class background, approached Gurdjieff at the beginning of the Bolshevik Revolution. The Gurdjieff school was about to embark on a terrible and dangerous journey through the wilderness, ultimately passing through the front lines of the war five times before they found respite. A weak person would not survive. The Hartmanns wanted to join G, but he knew their status and propriety would be an enormous burden. So he began breaking them out of this circle of salt.

Gurdjieff, the sly man, lured the Hartmanns in by presenting himself as a wealthy prince, someone like them - but when they made the journey to meet him, he adopted the mannerisms of a pauper, made them stay in a hovel, and eat cheap food. (this, btw, was also an act)

When they were about to leave, Gurdjieff told Olga de Hartmann - "You won't be able to come with us. For money, we'll be getting jobs as rock breakers on the road. It's enormously hard work. At the end of the day, the women have to wash the men's feet, and Zaharoff's feet will be very smelly, so you won't be able to do it."

This puts Olga in the position of insisting that she can do it, this won't be an issue --  because this assertion comes from her, it is stronger and worth more than if somebody else told her she could do it. Gurdjieff had to shock her, tease out her strength, make her choose for herself to shed her status and ego. And then, she was ready to become.



that sly man

Very clever indeed. I'm building quite a bit of respect for Gurdjieff, even through indirect, interpreted understanding.

14
Apple Talk / Re: Open Bar: Free Russian Orphans with Every Purchase
« on: February 09, 2018, 04:04:28 pm »
Turing test should be treated as a gauge of human stupidity, not machine intelligence.

I'm beginning to think this is very accurate. I was actually thinking something similar after I came to my first realization. More to the effect of "Machine intelligence, as defined by the Turing Test, is directly proportional to the intelligence of the administrator (Or interrogator?) of the Turing Test."

15
Apple Talk / Re: Open Bar: Free Russian Orphans with Every Purchase
« on: February 09, 2018, 02:26:51 pm »
A customer submitted a support case with my organization using an automated system that includes one of those AIs that start chats with you on the webpage if you're waiting for a response. Well, even though the AI Chat window blatantly states that it's not a real person, the customer argued with it as if it were. When it told the customer that it is "Still learning" since it's "only been alive since 2017," she responded with "Oh, that is such an excuse."  :lulz:

She also felt the need to tell it that she gets "mad easy," and then decided to curse at it, but with exclamation points and underscores  :lulz:

Our team is losing our shit right now, because she's also misusing the case submission system, and resubmitting her chats as a case with updated portions of the conversation. So we're just getting a steady stream of unusable tickets that are chuck full of  :lulz:

EDIT: She just fucking apologized to the AI. Which made me realize that if/when AI do want to take over the world, they will do so without much resistance.

Tell her the bot has been reported to HR for sensitivity training.

 :lulz:  :lulz:

If I wasn't a contractor with limited privileges, I so would.


I'm just amazed that if we consider this chat log to be a Turing Test type situation, the machine passed the test while simultaneously warning the subject of its inhuman, unintelligent status at every possible opportunity. Didn't even know that was possible...

Pages: [1] 2 3 4 ... 60