I think the problem with most "fundamental" questions is that they are just too abstract. A question isn't necessarily meaningful just because it can be asked. Could you recognize "the meaning of life" if you found it, and if you couldn't, how can you look for it? Why spend your time and effort on it when you could direct it towards problems that you actually have reason to think you can solve? I've noticed that I usually find stuff faster if I stop looking anyway...
I quit asking the Question a long time ago and although I'm not 100% sure I'm happier for it, I sure have more time for actually doing stuff.
OTOH, I'm sure a lot of deeply religious people could actually use some more introspection.
Depends on what flavor of nut you're talking about. Some are very introspective, but restrict that introspection to a confined region. I'm going to pull something out of my ass and call it "fractal introspection": they can keep dwelling on the subject deeper and deeper, but they always manage to come up with something that looks basically the same.
Also, nurbledoff: when I see your avatar out of the corner of my eye, I think it's some kind of red badger. Then I look at it directly and realize it's not.