You're right about the Discord thing. But general discord is just the easiest goal to achieve, not the only one that can be achieved, imho.
Of course, if we're carrying out this experiment as the Discordian Society, it stands to reason our means will lie almost exclusively within the realm of sowing discord, which is great. I just think that the Smart Meme will be able to target the areas where discord ought to be sown -- not so much an "endorsement" of Obama or an "attack" on Clinton, but as a way to bring attention to the fallacies of rhetorical speech and political spin and things like that.
Back on the topic of physical presence, I don't see why that matters. Even in your immediate vicinity, how many of the big names that effect you locally are actually real people to you? In my own town which is pretty small, the mayor might as well live in another country. It is the appearance of locality that matters, moreso than actually being locally present. There are 60,000 people in a 10-mile radius of me who mean exactly jack shit to me. The few people around here who do "matter" are no more than names in the newspaper or local radio anyway. It sounds cynical, but the isolation of the digital age actually assists us in this respect.
<brainstorm>
traditional methods of political discourse are going to be saturated and people will be in full-tilt 'filter my information' mode, although they will also be more acutely aware of buzzwords. we can use this fact to our advantage by focusing memes not on candidates or overt political agendas but by attacking the idea-base of ideas that are central to the campaign, in a way that seems unrelated or only tangentially related to the campaigns themselves.
for example, an operation to undermine the validity of experience in any endeavor, but specifically not mentioning politics: Study: Sexual Abuse Rates Climb with Clergy Experience.
also, turn Clinton's lines of attack into laughing stock by highlighting the absurd nature of extreme forms of these lines of attack. for example, Clinton loves to say Obama's healthcare plan leaves out 15 million americans, so apply her logic to something obviously false: County Schoolboard Denies Diplomas to Over 5,000 High School Dropouts
etc.