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Cocaine Vaccine

Started by AFK, October 07, 2009, 03:40:25 PM

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Quote from: Suu on November 01, 2009, 09:37:28 PM
And by making cocaine lose it's effect, it makes you stop wanting to take it.

In light of intending to quit, any relapses in the regimen are less rewarding than expected.  While tolerance is effectively increased, the feeling of reward involved with taking the accustomed dose is so much below the slow leak of tolerance that the addict might actually keep quitting.

"This sucks.  Why did I want to do this again?"  Basically, it serves as a soft negative reinforcement.

MornTheOrator

Quote from: Suu on November 01, 2009, 09:37:28 PM
And by making cocaine lose it's effect, it makes you stop wanting to take it.
Sure, that's the basic thing about quitting an addiction, you build of slowly until you don't need it any more.

The catch is you need willpower to reduce it because it's hard. So, that's why most people don't quit.
The effect is also lessened by just taking less cocaine, the classic approach, also a lot cheaper, and people don't do that because they lack willpower and can't restrain themselves from taking the same amount. So if it loses its effect because of this so people that have the willpower to just take the same amount could just as well not take the drug and take less a lot cheaper on both fronts. Or they can't restrain thesmelves and they take more to compensate for the effect.

Also, because this thing apparently uses the human immune system.. I would find it plausible that the reason cocaine usually loses its effect over time is because of the human immune system, it could also be simply be that the receptors in your brain get dulled, I'm no immunologist. But if the former, it just speeds up the process of that drugs start to lose their effect after a while, which is seen as one of the dangerous factors because you keep needing more and more to achieve the same result so cost increases with time.

MornTheOrator

Quote from: MornTheOrator on November 01, 2009, 10:16:41 PM
Quote from: Suu on November 01, 2009, 09:37:28 PM
And by making cocaine lose it's effect, it makes you stop wanting to take it.
Sure, that's the basic thing about quitting an addiction, you build of slowly until you don't need it any more.

The catch is you need willpower to reduce it because it's hard. So, that's why most people don't quit.
The effect is also lessened by just taking less cocaine, the classic approach, also a lot cheaper, and people don't do that because they lack willpower and can't restrain themselves from taking the same amount. So if it loses its effect because of this so people that have the willpower to just take the same amount could just as well not take the drug and take less a lot cheaper on both fronts. Or they can't restrain thesmelves and they take more to compensate for the effect.

Also, because this thing apparently uses the human immune system.. I would find it plausible that the reason cocaine usually loses its effect over time is because of the human immune system, it could also be simply be that the receptors in your brain get dulled, I'm no immunologist. But if the former, it just speeds up the process of that drugs start to lose their effect after a while, which is seen as one of the dangerous factors because you keep needing more and more to achieve the same result so cost increases with time.

Quote from: yhnmzw on November 01, 2009, 10:15:20 PM
Quote from: Suu on November 01, 2009, 09:37:28 PM
And by making cocaine lose it's effect, it makes you stop wanting to take it.

In light of intending to quit, any relapses in the regimen are less rewarding than expected.  While tolerance is effectively increased, the feeling of reward involved with taking the accustomed dose is so much below the slow leak of tolerance that the addict might actually keep quitting.

"This sucks.  Why did I want to do this again?"  Basically, it serves as a soft negative reinforcement.
That's an amazingly strange strategy because 1: you rely on individual psychology of people, not all people are going to think like that. 2: give them a placebo or at least less effective cocaine that looks the same?

The Good Reverend Roger

#33
Quote from: Nigel on October 31, 2009, 09:22:32 PM
Quote from: MornTheOrator on October 31, 2009, 08:12:01 PM
I'm trying deeply to find beneficial effect of this drug that seems to be a cocaine blocker that uses the immune system as a bypass that goes far beyond simply taking less cocaine, or taking no cocaine at all. Thus far I am bested by this problem of life.

Maybe one day.

It's for addicts who want to quit but are having a hard time.

You have to remember that Morn considers herself above all other humans and their problems.

Which is funny, given that she's into lolicon and incest.


http://who.nihilarchitect.net/
Quote from: who.niarch.netMy dearest brother is a graphic artist and musician, whose interests include, in non-particular order, [quasi-]incestuous business with me - his most beloved sister -, linguistics, black ambient, lolicon, 'emo-black metal', writing rants about everything he hates (which is everything - Just for example: Shining-posers whose 'mission' is to lure their poser-followers into suicide, claiming to be 'suicidal black metal' and all that, while they play nothing but accessible doom metal and I'm basically trying to make the point here that the unfortunately incredibly small amount of people like my beloved brother are way too tr00 kvlt gr1mm for bands such as Shining with a clear production and a gay vocalist who seems to be wearing his handkerchief on his balding head all the time so no one will know that his skull is actually covered with scabs that make his head look like a rotting piece of fruit. Anyway. It's been stated obvious that DSBM will only be likeable for those like my brother with a production comparable to the lovely sound of a vacuum cleaner and free of Shining-kids), irritating his little ignorant sister with incredibly complex math formulas[sic], British English and cute little Asian girls. Currently he is working on several projects. æon nought can be described as cellar-like black ambient, with tortured screams and dreamy soundscapes. emotion:i:void is a DSBM and dark ambient project with samples in his own constructed language Rakharniadjirn. The last project I will mention here is also my personal favourite, Lajlia, a project mainly dealing with dreams and nightmares, childlike innocence and hopes. Most of his projects saw the light of day after he studied physics and mathematics for a year, and failed terribly because he is too awesome. His appearance as a dark figure in a black robe with long fingers sticking out of the sleeves might be somewhat intimidating (as for the long fingers: investigations on his DNA are still running. My brother may be a hybrid of some sort, crossed with a long-fingered alien that can play the piano virtuously and make mister Soerjadi wince) but in fact my brother is a highly sensitive person, [aptly able] to read your mood and emotions through a chat screen. Apart from his extremely high intelligence and numerous artistic abilities he also has a superb sense of humour and he is very talented in making fun of stereotypes. Bookings and reservations cannot be arranged.

ETA:  "She" is a "He", which he lied about.  Now he's trying to say that he really isn't into incest and lolicon.  I'm sure he's not lying now, right?  RIGHT RIGHT RIGHT?

Yay.  Another predator of children.
" It's just that Depeche Mode were a bunch of optimistic loveburgers."
- TGRR, shaming himself forever, 7/8/2017

"Billy, when I say that ethics is our number one priority and safety is also our number one priority, you should take that to mean exactly what I said. Also quality. That's our number one priority as well. Don't look at me that way, you're in the corporate world now and this is how it works."
- TGRR, raising the bar at work.

Thurnez Isa

Quote from: The Good Reverend Roger on November 01, 2009, 10:30:07 PM

You have to remember that Morn considers herself above all other humans and their problems.



I've read part of the blog

trust me... she isn't
Through me the way to the city of woe, Through me the way to everlasting pain, Through me the way among the lost.
Justice moved my maker on high.
Divine power made me, Wisdom supreme, and Primal love.
Before me nothing was but things eternal, and eternal I endure.
Abandon all hope, you who enter here.

Dante

The Good Reverend Roger

Quote from: Thurnez Isa on November 01, 2009, 10:41:36 PM
Quote from: The Good Reverend Roger on November 01, 2009, 10:30:07 PM

You have to remember that Morn considers herself above all other humans and their problems.



I've read part of the blog

trust me... she isn't

He.

He thinks Volkert van der Graaf is just fascinating.  Kim Jon Il, too.  And Joe Stalin.  And phallic symbols, which are everywhere, doncha know.
" It's just that Depeche Mode were a bunch of optimistic loveburgers."
- TGRR, shaming himself forever, 7/8/2017

"Billy, when I say that ethics is our number one priority and safety is also our number one priority, you should take that to mean exactly what I said. Also quality. That's our number one priority as well. Don't look at me that way, you're in the corporate world now and this is how it works."
- TGRR, raising the bar at work.

MornTheOrator

What... happened.. here?

Oh well, let's get some popcorn shall we. Besides, Volkert is pretty fascinating and so is Kim Jong Il, you have to admit they grab your curiosity.

Thurnez Isa

Quotes  Attaining high (≥43 µg/mL) IgG anticocaine antibody levels was associated with significantly reduced cocaine use, but only 38% of the vaccinated subjects attained these IgG levels and they had only 2 months of adequate cocaine blockade. Thus, we need improved vaccines and boosters.

http://archpsyc.ama-assn.org/cgi/content/abstract/66/10/1116

the article linked may have been more optimistic then let on
Through me the way to the city of woe, Through me the way to everlasting pain, Through me the way among the lost.
Justice moved my maker on high.
Divine power made me, Wisdom supreme, and Primal love.
Before me nothing was but things eternal, and eternal I endure.
Abandon all hope, you who enter here.

Dante

Template

Quote from: Thurnez Isa on November 01, 2009, 10:46:42 PM
Quotes  Attaining high (≥43 µg/mL) IgG anticocaine antibody levels was associated with significantly reduced cocaine use, but only 38% of the vaccinated subjects attained these IgG levels and they had only 2 months of adequate cocaine blockade. Thus, we need improved vaccines and boosters.

http://archpsyc.ama-assn.org/cgi/content/abstract/66/10/1116

the article linked may have been more optimistic then let on

I'm not surprised.  I read a paper on essentially this topic years ago.

Thurnez Isa

Quote from: The Good Reverend Roger on November 01, 2009, 10:44:18 PM
Quote from: Thurnez Isa on November 01, 2009, 10:41:36 PM
Quote from: The Good Reverend Roger on November 01, 2009, 10:30:07 PM

You have to remember that Morn considers herself above all other humans and their problems.



I've read part of the blog

trust me... she isn't

He.

He thinks Volkert van der Graaf is just fascinating.  Kim Jon Il, too.  And Joe Stalin.  And phallic symbols, which are everywhere, doncha know.

oh one of those

basically it's like a bad direct to video sequel,
same shit as before, just cheaper and less effective
Through me the way to the city of woe, Through me the way to everlasting pain, Through me the way among the lost.
Justice moved my maker on high.
Divine power made me, Wisdom supreme, and Primal love.
Before me nothing was but things eternal, and eternal I endure.
Abandon all hope, you who enter here.

Dante

The Good Reverend Roger

Quote from: Thurnez Isa on November 01, 2009, 10:48:53 PM
Quote from: The Good Reverend Roger on November 01, 2009, 10:44:18 PM
Quote from: Thurnez Isa on November 01, 2009, 10:41:36 PM
Quote from: The Good Reverend Roger on November 01, 2009, 10:30:07 PM

You have to remember that Morn considers herself above all other humans and their problems.



I've read part of the blog

trust me... she isn't

He.

He thinks Volkert van der Graaf is just fascinating.  Kim Jon Il, too.  And Joe Stalin.  And phallic symbols, which are everywhere, doncha know.

oh one of those

basically it's like a bad direct to video sequel,
same shit as before, just cheaper and less effective

He also likes lolicon and banging his own sister.  Bit of a freak, actually.

But definitely someone who has obviously earned the right to look down his nose at people who are having trouble kicking a cocaine addiction.

:lulz:
" It's just that Depeche Mode were a bunch of optimistic loveburgers."
- TGRR, shaming himself forever, 7/8/2017

"Billy, when I say that ethics is our number one priority and safety is also our number one priority, you should take that to mean exactly what I said. Also quality. That's our number one priority as well. Don't look at me that way, you're in the corporate world now and this is how it works."
- TGRR, raising the bar at work.

Template

Quote from: MornTheOrator on November 01, 2009, 10:17:58 PM
Quote from: yhnmzw on November 01, 2009, 10:15:20 PM
Quote from: Suu on November 01, 2009, 09:37:28 PM
And by making cocaine lose it's effect, it makes you stop wanting to take it.

In light of intending to quit, any relapses in the regimen are less rewarding than expected.  While tolerance is effectively increased, the feeling of reward involved with taking the accustomed dose is so much below the slow leak of tolerance that the addict might actually keep quitting.

"This sucks.  Why did I want to do this again?"  Basically, it serves as a soft negative reinforcement.
That's an amazingly strange strategy because 1: you rely on individual psychology of people, not all people are going to think like that. 2: give them a placebo or at least less effective cocaine that looks the same?

1.  It's meant to be one available tool.  Its usefulness in fact depends on the addict's personality.  It's not just strange--it's lateral thinking!
2.  Can't be seen to give addicts the drug they need, not even a placebo.  Law, and all.  If it were that easy, there'd be little reason to quit!

The Good Reverend Roger

" It's just that Depeche Mode were a bunch of optimistic loveburgers."
- TGRR, shaming himself forever, 7/8/2017

"Billy, when I say that ethics is our number one priority and safety is also our number one priority, you should take that to mean exactly what I said. Also quality. That's our number one priority as well. Don't look at me that way, you're in the corporate world now and this is how it works."
- TGRR, raising the bar at work.

Template


The Good Reverend Roger

Quote from: yhnmzw on November 01, 2009, 10:52:17 PM
Quote from: The Good Reverend Roger on November 01, 2009, 10:51:06 PM
Quote from: MornTheOrator on November 01, 2009, 10:46:23 PM
What... happened.. here?


PEEDEE happened.

TGRR, where/how did you get the blog link or whatever?

Me and another have been doing a little digging, is all.  The other one found it, the pedo (Morn) fessed up to it (in the intros thread), in fact is very proud of having the "courage" to post that he's fucking his sister and looking at pedo porn.
" It's just that Depeche Mode were a bunch of optimistic loveburgers."
- TGRR, shaming himself forever, 7/8/2017

"Billy, when I say that ethics is our number one priority and safety is also our number one priority, you should take that to mean exactly what I said. Also quality. That's our number one priority as well. Don't look at me that way, you're in the corporate world now and this is how it works."
- TGRR, raising the bar at work.