Author Topic: Space dogs  (Read 2639 times)

Mesozoic Mister Nigel

  • v=1/3πr2h
  • Deserved It
  • ****
  • Posts: 687093
  • The sky tastes like red exuberance.
    • View Profile
Re: Space dogs
« Reply #45 on: November 30, 2016, 11:36:10 pm »
Self-replicating is the current sticking point for most definitions of life, and is the reason viruses, which very nearly qualify as "alive", are in a gray area.
Im guessing it was January 2007, a meeting in Bethesda, we got a bag of bees and just started smashing them on the desk, Charles Wick said. It was very complicated.


Trivial

  • Corporate Drone #5235
  • Deserved It
  • ****
  • Posts: 17802
  • No
    • View Profile
Re: Space dogs
« Reply #46 on: December 01, 2016, 02:27:28 am »
Self-replicating is the current sticking point for most definitions of life, and is the reason viruses, which very nearly qualify as "alive", are in a gray area.

Prions are another I would think.
Sexy Octopus of the Next Noosphere Horde

There are more nipples in the world than people.

Mesozoic Mister Nigel

  • v=1/3πr2h
  • Deserved It
  • ****
  • Posts: 687093
  • The sky tastes like red exuberance.
    • View Profile
Re: Space dogs
« Reply #47 on: December 02, 2016, 04:51:30 am »
Self-replicating is the current sticking point for most definitions of life, and is the reason viruses, which very nearly qualify as "alive", are in a gray area.

Prions are another I would think.

Not exactly, because they don't "replicate" per se, but rather are a contagious form of misfolding protein that nobody really understands. They're like the shitty memes of the protein world.
Im guessing it was January 2007, a meeting in Bethesda, we got a bag of bees and just started smashing them on the desk, Charles Wick said. It was very complicated.


Trivial

  • Corporate Drone #5235
  • Deserved It
  • ****
  • Posts: 17802
  • No
    • View Profile
Re: Space dogs
« Reply #48 on: December 02, 2016, 04:28:52 pm »
Self-replicating is the current sticking point for most definitions of life, and is the reason viruses, which very nearly qualify as "alive", are in a gray area.

Prions are another I would think.

Not exactly, because they don't "replicate" per se, but rather are a contagious form of misfolding protein that nobody really understands. They're like the shitty memes of the protein world.

Do they work like ice 9?  I can't think of something normal to conceptualise. 
Sexy Octopus of the Next Noosphere Horde

There are more nipples in the world than people.

Mesozoic Mister Nigel

  • v=1/3πr2h
  • Deserved It
  • ****
  • Posts: 687093
  • The sky tastes like red exuberance.
    • View Profile
Re: Space dogs
« Reply #49 on: December 02, 2016, 04:51:56 pm »
Self-replicating is the current sticking point for most definitions of life, and is the reason viruses, which very nearly qualify as "alive", are in a gray area.

Prions are another I would think.

Not exactly, because they don't "replicate" per se, but rather are a contagious form of misfolding protein that nobody really understands. They're like the shitty memes of the protein world.

Do they work like ice 9?  I can't think of something normal to conceptualise.

I'm not sure how ice 9 is supposed to work in the book, I don't recall it being heavy on technical details. Prions seem to act like a template that induces normal proteins in contact with the prion protein to re-fold into a nonfunctional form.

https://hegemony.wordpress.com/2006/11/21/how-do-prions-work/
Im guessing it was January 2007, a meeting in Bethesda, we got a bag of bees and just started smashing them on the desk, Charles Wick said. It was very complicated.


Mesozoic Mister Nigel

  • v=1/3πr2h
  • Deserved It
  • ****
  • Posts: 687093
  • The sky tastes like red exuberance.
    • View Profile
Re: Space dogs
« Reply #50 on: December 02, 2016, 05:05:29 pm »
Viruses have DNA, but they lack the replicative machinery with which to duplicate or transcribe it. That's why they hijack the cellular machinery of other organisms. One hypothesis about viruses is that they were originally parasitic organisms that gradually jettisoned their own cellular machinery. Prions, on the other hand, have no DNA at all, and simply seem to have a contact effect of inducing other proteins to misfold.
Im guessing it was January 2007, a meeting in Bethesda, we got a bag of bees and just started smashing them on the desk, Charles Wick said. It was very complicated.


Trivial

  • Corporate Drone #5235
  • Deserved It
  • ****
  • Posts: 17802
  • No
    • View Profile
Re: Space dogs
« Reply #51 on: December 02, 2016, 06:58:32 pm »
Self-replicating is the current sticking point for most definitions of life, and is the reason viruses, which very nearly qualify as "alive", are in a gray area.

Prions are another I would think.

Not exactly, because they don't "replicate" per se, but rather are a contagious form of misfolding protein that nobody really understands. They're like the shitty memes of the protein world.

Do they work like ice 9?  I can't think of something normal to conceptualise.

I'm not sure how ice 9 is supposed to work in the book, I don't recall it being heavy on technical details. Prions seem to act like a template that induces normal proteins in contact with the prion protein to re-fold into a nonfunctional form.

https://hegemony.wordpress.com/2006/11/21/how-do-prions-work/

Ice 9 made water crystallize at room temp because it was a more stable configuration.  Basically any water that touched it would become ice 9.

It wasn't more technical than that though.  Was just thinking of how a prion would turn any normal protein into a prion.
Sexy Octopus of the Next Noosphere Horde

There are more nipples in the world than people.

Mesozoic Mister Nigel

  • v=1/3πr2h
  • Deserved It
  • ****
  • Posts: 687093
  • The sky tastes like red exuberance.
    • View Profile
Re: Space dogs
« Reply #52 on: December 02, 2016, 07:21:28 pm »


Ice 9 made water crystallize at room temp because it was a more stable configuration.  Basically any water that touched it would become ice 9.

It wasn't more technical than that though.  Was just thinking of how a prion would turn any normal protein into a prion.

Yeah, that's what I remember of it. That's also about all we know about how prions work.
Im guessing it was January 2007, a meeting in Bethesda, we got a bag of bees and just started smashing them on the desk, Charles Wick said. It was very complicated.


LMNO

  • Lubricated and Rabid Lungfish of Impending Sexdoom
  • Deserved It
  • ****
  • Posts: 87074
  • Internet Fuckweasel of Haunted Pork Dimensions.
    • View Profile
    • Earfatigue Productions: When it has to sound like you give a shit.
Re: Space dogs
« Reply #53 on: December 02, 2016, 07:37:12 pm »
Is it OK to say that prions kind of scare me?

Mesozoic Mister Nigel

  • v=1/3πr2h
  • Deserved It
  • ****
  • Posts: 687093
  • The sky tastes like red exuberance.
    • View Profile
Re: Space dogs
« Reply #54 on: December 02, 2016, 07:51:30 pm »
Is it OK to say that prions kind of scare me?

They are scary as fuck, so I'm gonna go with not only OK, but eminently reasonable. Contagious proteins that shut down your brain are a legitimate thing to be freaked the fuck out about.
Im guessing it was January 2007, a meeting in Bethesda, we got a bag of bees and just started smashing them on the desk, Charles Wick said. It was very complicated.


P3nT4gR4m

  • Official SSOOKN Pariah
  • Deserved It
  • ****
  • Posts: 72172
  • I'm an artist now - isn't that depressing?
    • View Profile
    • fuck you
Re: Space dogs
« Reply #55 on: December 02, 2016, 08:24:11 pm »
Okay so now I'm freaked the fuck out about this prions shit. I think we may owe it to the world to spread mass-panic
Not actually a meat product.
Ass-Kicking & Foot-Stomping Ancient Master of SHIT FUCK FUCK FUCK
Awful and Bent Behemothic Results of Last Night's Painful Squat.
High Altitude Haggis-Filled Sex Bucket From Beyond Time and Space.
Internet Monkey Person of Filthy and Immoral Pygmy-Porn Wart Contagion
Octomom Auxillary Heat Exchanger Repairman
walking the fine line line between genius and batshit fucking crazy

"computation is a pattern in the spacetime arrangement of particles, and its not the particles but the pattern that really matters! Matter doesnt matter." -- Max Tegmark

Mesozoic Mister Nigel

  • v=1/3πr2h
  • Deserved It
  • ****
  • Posts: 687093
  • The sky tastes like red exuberance.
    • View Profile
Re: Space dogs
« Reply #56 on: December 02, 2016, 08:55:23 pm »
Okay so now I'm freaked the fuck out about this prions shit. I think we may owe it to the world to spread mass-panic

Already happened; remember Mad Cow Disease?
Im guessing it was January 2007, a meeting in Bethesda, we got a bag of bees and just started smashing them on the desk, Charles Wick said. It was very complicated.


Trivial

  • Corporate Drone #5235
  • Deserved It
  • ****
  • Posts: 17802
  • No
    • View Profile
Re: Space dogs
« Reply #57 on: December 02, 2016, 09:25:15 pm »
https://en.wikipedia.org/wiki/Fatal_familial_insomnia

So some people have genes that make these damn things. 
Sexy Octopus of the Next Noosphere Horde

There are more nipples in the world than people.

P3nT4gR4m

  • Official SSOOKN Pariah
  • Deserved It
  • ****
  • Posts: 72172
  • I'm an artist now - isn't that depressing?
    • View Profile
    • fuck you
Re: Space dogs
« Reply #58 on: December 02, 2016, 09:50:27 pm »
https://en.wikipedia.org/wiki/Fatal_familial_insomnia

So some people have genes that make these damn things. 

One word -  death camps
Not actually a meat product.
Ass-Kicking & Foot-Stomping Ancient Master of SHIT FUCK FUCK FUCK
Awful and Bent Behemothic Results of Last Night's Painful Squat.
High Altitude Haggis-Filled Sex Bucket From Beyond Time and Space.
Internet Monkey Person of Filthy and Immoral Pygmy-Porn Wart Contagion
Octomom Auxillary Heat Exchanger Repairman
walking the fine line line between genius and batshit fucking crazy

"computation is a pattern in the spacetime arrangement of particles, and its not the particles but the pattern that really matters! Matter doesnt matter." -- Max Tegmark

Mesozoic Mister Nigel

  • v=1/3πr2h
  • Deserved It
  • ****
  • Posts: 687093
  • The sky tastes like red exuberance.
    • View Profile
Re: Space dogs
« Reply #59 on: December 02, 2016, 10:25:59 pm »
Im guessing it was January 2007, a meeting in Bethesda, we got a bag of bees and just started smashing them on the desk, Charles Wick said. It was very complicated.