a salient criticism of Hoffman's hypothesis that our perceptual reality has no pressure to conform to actual reality:
The faculty of perception is based upon recognition. The "accuracy" or "fitness" thereof is provided by natural selection, both determining survivability of the organism at the macro level, and reinforcing connections reproduced at the micro/neuronal.
Don't be fooled by the word "microbiology"; it is the study of microbial life, not the study of subatomic particles. Even a cellular level is macro when we are talking about particle behavior, which is the level at which quantum behavior manifests. So, nope.
The above distinction between macro and micro indicates that the premise of recognition obtaining a benefit from accuracy operates at different levels or scales of spatio-temporal extension. So, yeah, however a fool I do remain, always 
It's fundamentally no different to think about than individual variations disappearing in the mean of a large group sample. Any kind of probability-based differences in outcome vanish into a probability curve when you have a large sample size. Any time you are looking at any biologically-sized molecule, you are looking at an object with a large enough population of subatomic particles that quantum behavior - that is, probabilistic behavior - disappears into a probability curve, leaving the molecule as a whole with deterministic behavior rather than quantum (probability-based) behavior. For example, think about coin tosses: each individual coin toss has 50/50 probability, and the fewer coin tosses you make, the less well you can predict the distribution of heads and tails. If you toss the coin 5 times, it might come up heads all 5 times, just by chance. However, if you toss the coin 5000 times, the sum distribution of those tosses will be very very close to 50/50. That is what quantum particle behavior is like, and that's why it isn't applicable on a macro (biological) scale. There may be some exceptions; it is actually possible that our sense of smell may involve some aspect of quantum detection. However, that is as yet undetermined.
I don't know if that's how a physicist would explain it, but I'm not a physicist.