Messages

  and, yes, that stool belongs on the floor, for fuck the tender blod-clot theif, lest his diverticulitis is up for another asymptotic venture to curb his bleeding mug on the bar.

Reminds me of the barstool experiment:

Zeno disputes the check, belaboring the point that he still thinks they were given more than they were ever going to order.

...and then the bartender picks up a barstool and beats you and Zeno to death with it.

My K9 powers of golden retrieval need to hit the sack, but I was going to suggest including/substituting "chaos" to the "entropy" search string...  This 48 hr day too haws passed

When in doubt, quote 1 John 2:9:

Anyone who claims to be in the light but hates a brother or sister is still in the darkness.

True dat.  And if the hate is veiled, then, disparaging or invidious comparisons to the order of what I am not, generally, need not be addressed to yours truly.  That's just good manners 

Today during a therapy session, i caused my counselor to ask, with a straight face, the question, " But is going to a music show at a coffeshop as risky as summoning a horde of the undead?"

he immediately followed up with, "That is the weirdest question I have ever asked."

I like therapy.

Say, Doc., what do you know about countertransference ...

 

Just this last one. 






[editing pix caused some links above to stop working, simple machines maybe performs checksum ]

Thank you Paes 

I done did made it some less sloppy now:

To switch gears for a moment, Twid, I was wondering (what with the diversity of your research background) whether you have had occasion to learn much about Huntington's Disease? If I get into the Honors College I am thinking about researching some aspect it as part of my senior thesis. I'm not sure I can shoehorn it into the "urban" theme, but I can try!

I'm also considering seeing if I can document the disappearing small towns of Oregon as a side effect of the urbanization process for my thesis. It's a bit of a stretch but might be more directly applicable to the urban theme than Huntington's.

It migt be possible to correlate HD neurodegeneration with the effects of stress caused by the process of urbanization:

Antidepressants are widely used in the treatment of HD patients (Sackley et al., 2011). Recent studies suggest that chronic treatment with the SSRIs fluoxetine or sertraline increased hippocampal neurogenesis, ameliorated cognitive deficits, and depression-like behavioral symptoms in R6/1 mice (Grote et al., 2005; Renoir et al., 2012) and increased BDNF levels and neurogenesis in R6/2 mice (Peng et al., 2008). Chronic antidepressant treatment in depressed patients resulted in upregulation of CREB protein expression (Nibuya et al., 1996), CREB phosphorylation (Saarelainen et al., 2003), BDNF (Chen et al., 2001), and TrkB (Bayer et al., 2000) in the hippocampus. BDNF has been proposed to be a mediator of the effects of antidepressants (Koponen et al., 2005), by augmenting the survival and differentiation of adult-born neurons in the dentate gyrus (Groves, 2007). These results led to the hypothesis that depression in HD coincides with decreased activity in the serotonin-CREB-BDNF-TrkB pathway, resulting in cellular dysfunction and reduced neurogenesis in the hippocampus.

So daily survival stress, jail, home displacement, poor living conditions...

The link between HPA-axis, depression, and BDNF has been explored in rodent models of depression and given much attention. Social stress has been widely used as a useful model of depression (Henn and Vollmayr, 2005). Stressors such as forced immobilization (Smith et al., 1995) and social defeat (Pizarro et al., 2004) were found to decrease BDNF expression in the hippocampus and cortical and subcortical regions of rodent models. Induced elevation of corticosterone, mimicking the effect of stress, has also been associated with reduced levels of BDNF mRNA and protein in the hippocampus and frontal cortex of rodent models (Schaaf et al., 1997, 1998; Chao et al., 1998; Dwivedi et al., 2006). Adrenalectomy surgery caused an increase of BDNF in the hippocampus (Chao et al., 1998), whilst chronic GR activation reduces both CREB phosphorylation and BDNF expression (Focking et al., 2003). This suggests regulatory ability of glucocorticoids on BDNF expression. GR was also found to interact with the BDNF receptor TrkB and corticosterone reduces TrkB-GR interaction, causing reduced BDNF-triggered glutamate release and BDNF-stimulated PLC-γ (Numakawa et al., 2009). Thus, taken together, increased HPA-axis activity may initiate a chain reaction, leading to altered 5-HT signaling, reduced CREB-mediated transcription of BDNF and damage to the hippocampus and other brain regions, which in turn, reduces negative feedback on the HPA-axis in a negative cycle  may be impacted by environmental modulators, such as the cognitive stimulation and physical exercise induced by environmental enrichment. Complex gene–gene interactions and associated gene-environment interactions are presumably responsible for the variable incidence of depression both within HD patients (where each tandem repeat expansion mutation is embedded in a genome possessing a range of genetic modifiers) and the general population. Elucidation of this complexity at molecular, cellular, and systems levels will require a new generation of sophisticated animal models and clinical investigations.​

https://dx.doi.org/10.3389/fneur.2013.00081

Just some thoughts?

Sometime environmental factors of pathogenesis are neglected when we figure all the genetics have been solved, in principle.

It's dead... All of it... Equestria...MLP...

https://www.youtube.com/watch?v=NjlYvI7Q-bA

https://www.youtube.com/watch?v=k0UbAg7lspM&; 

Cool!

Thank you - still saved myself a slice of "...currency" that I'm going to enjoy after lunch - things are looking good 

Wow, that's very well done. 

1. Is it yours? (had to ask)
2. Is it Kopyleft?

1) Yes
2) Yes (and DSL, just for diligence

I enjoy that you enjoy

[Ed. Should I just mv this to Copyleft thread?]
[I'm starting to think the penmanship is too raw and sloppy - It needs to spend more time in inkskape.  And maybe first "r" should be lower case...  I'm thinking too much about this]

Still giddy as a schoolgirl after what I'm embarrassed to say caused me to lose all propriety:  the sudden appearance of that star.  I ran to beach last night ululating madness at the moon that lay itself before me on crescent waves across the sea.  In referential madness I noticed a smoldering, amorphous beast, surrounded by a circle of light.  My, I say, what tenebrous monsters these delinquents dredge up in these here strange times.

Feeling that cawing thing on the back of my neck, I decide to head back home.  Passing under a bridge, I'm suddenly blinded by a spot-light from a vehicle up the hill toward my pad.  Now, what with the extra gravity of that star, together with the chthonic pyre, and now this very bright light in my face, I figured I'd swagger my way right up there...

Turns out it was 5-0...  I mean, that's cool, I flashed them with my tactical LED...

Something needed to be done about that last encounter, so I sacrificed a virgin and let her freshly spilt blood guide my brush.  The result was a map of directions, to dispel Satan's minions  Really, they can't read this shit and it drives them crazy.   

Wasps are scavengers of the worst kind.  They value what they steal more than anything else.

I'd rather dance with a bee.

Been doing that all day, too.

-Suu
lives dangerously...and has a stingy thingy infested balcony.

I love bees, so the exterminator idea kinda rubs me the wrong way.  Given it might still be inevitable, there is perhaps something you could try during the interim, before administering any final solutions.

1). Choose relatively proximate neighbor - within throwing distance, just not directly adjacent  - one that does not always behave
2). Get bottle of wintergreen essential oil from local health food store.
3). Empty bottle on suitably porous yet integral medium (wadded-up PT)
4)  Launch projectile/carrier to target 1) - nighttime is preferable.
5) Cheers, welcome to the Biological Warfare Club

This can accomplish 3 tasks
A) Fuck with misbehaving neighbor
B) Move bees of their own accord.
C) Lots of fun!

Plus the oil has analgesic and anti-inflammatory effects if it gets on you (DO NOT CONSUME).  It essentially is topical Aspirin: gets rid of pains.  I guess that's why they like it.  Handling instructions are similar to turpentine.  One fatality registered:  child overused topical application to knee for sport competition

-

OR, boil the whole hive (with bees) in a pot of water to use for next batch of Mugwort Beer.  Although that might not be vey nice, for the bees.
(ask me about other dancing critters, and I really couldn't say)

The wood bees aren't really the problem anymore. They buzz around you and try to front, but they're usually just curious and bolt.

...It was the fucking yellow jackets that came out of nowhere and chased off the wood bees.

I put peppermint oil on my screen door, and that seemed to have gotten rid of the wasps. The bees are still hanging around, but I already called maintenance about them. It's not that they will sting, it's that they're like termites, in bee form.

That reminds me I need to get a new coat of sealant for the balcony, thank you...  I don't know much about peppermint but perhaps the bees are attracted to it like wintergreen - unless it's just a selective wasp antagonist thingie (I can sometimes hardly tell the difference).

Reminds me of the barstool experiment:

Zeno disputes the check, belaboring the point that he still thinks they were given more than they were ever going to order.