Principia Discordia

Principia Discordia => Apple Talk => Topic started by: Mesozoic Mister Nigel on October 16, 2014, 12:43:29 AM

Title: So did you know
Post by: Mesozoic Mister Nigel on October 16, 2014, 12:43:29 AM
...that your skin has odor receptors?

Your whole body is a nose.

You're welcome.
Title: Re: So did you know
Post by: trix on October 16, 2014, 03:34:13 AM
no, but that explains a lot.
Title: Re: So did you know
Post by: LMNO on October 16, 2014, 12:20:05 PM
Well, anal just got a lot more... interesting.
Title: Re: So did you know
Post by: Cain on October 16, 2014, 12:27:32 PM
This almost sounds like something from the "did-yuo-know" tumblr.  Except for the fact its real, of course.

There has to be a niche tumblr audience for that, for things which are factual but sound like they're made up to sound factual.
Title: Re: So did you know
Post by: Doktor Howl on October 16, 2014, 03:21:05 PM
Quote from: Your Mom on October 16, 2014, 12:43:29 AM
...that your skin has odor receptors?

Your whole body is a nose.

You're welcome.

I know this on account of vindaloo.
Title: Re: So did you know
Post by: Mesozoic Mister Nigel on October 16, 2014, 03:25:53 PM
Quote from: Cain on October 16, 2014, 12:27:32 PM
This almost sounds like something from the "did-yuo-know" tumblr.  Except for the fact its real, of course.

There has to be a niche tumblr audience for that, for things which are factual but sound like they're made up to sound factual.

This idea has legs.
Title: Re: So did you know
Post by: Cain on October 16, 2014, 03:27:23 PM
Especially if it had links to well known parody sites in the sidebar.
Title: Re: So did you know
Post by: Mesozoic Mister Nigel on October 16, 2014, 03:41:33 PM
Quote from: Cain on October 16, 2014, 03:27:23 PM
Especially if it had links to well known parody sites in the sidebar.

:lulz: This is an entirely new twist on misinformation.
Title: Re: So did you know
Post by: Faust on October 16, 2014, 03:46:14 PM
Quote from: Your Mom on October 16, 2014, 12:43:29 AM
...that your skin has odor receptors?

Your whole body is a nose.

You're welcome.

How does this work, are their functions related to perspiration, heat detection etc?
Title: Re: So did you know
Post by: MMIX on October 16, 2014, 05:14:46 PM
Quote from: Faust on October 16, 2014, 03:46:14 PM
Quote from: Your Mom on October 16, 2014, 12:43:29 AM
...that your skin has odor receptors?

Your whole body is a nose.

You're welcome.

How does this work, are their functions related to perspiration, heat detection etc?

Quote
http://www.nytimes.com/2014/10/14/science/smell-turns-up-in-unexpected-places.html
"If you think of olfactory receptors as specialized chemical detectors, instead of as receptors in your nose that detect smell, then it makes a lot of sense for them to be in other places," said Jennifer Pluznick, an assistant professor of physiology at Johns Hopkins University who in 2009 found that olfactory receptors help control metabolic function and regulate blood pressure in the kidneys of mice."
People call them olfactory receptors because the first place that they identified these structures was in the noses of members of their own species.

QuoteHumans have about 350 different kinds of olfactory receptors, and that is on the low end for vertebrates. (Mice, and other animals that depend heavily on their sense of smell for finding food and evading predators, have more than 1,000.)

Quote"More than 15 of the olfactory receptors that exist in the nose are also found in human skin cells," said the lead researcher, Dr. Hanns Hatt.

Its still an interesting finding, though, with potential for the development of treatments which, historically, (and by that I mean right up to the day before the research was published) would have sounded as weird and off-the-wall as dowsing or dare I say homeopathy or any other "treatment" which sounds utterly unbelievable.


edit for missing punctuation
Title: Re: So did you know
Post by: Mesozoic Mister Nigel on October 16, 2014, 09:37:18 PM
Quote from: Faust on October 16, 2014, 03:46:14 PM
Quote from: Your Mom on October 16, 2014, 12:43:29 AM
...that your skin has odor receptors?

Your whole body is a nose.

You're welcome.

How does this work, are their functions related to perspiration, heat detection etc?

They work the same way as the ones in our noses do (detecting and recognizing odor molecules) but rather than routing that information through the thalamus for conscious recognition, they seem to serve a regulatory function, responding to certain odors by triggering biochemical cascades that regulate how our cells transcribe DNA to produce certain proteins. For example, for reasons no one understands, exposing the skin to the odor of sandalwood triggers a cascade that results in more rapid healing of wounds.

Title: Re: So did you know
Post by: trix on October 16, 2014, 09:43:25 PM
lol I wonder if I could hold my nose and still detect the scent of something strong and easily recognizable.
I want to try this experiment!
Title: Re: So did you know
Post by: Reginald Ret on October 16, 2014, 10:33:01 PM
Quote from: Your Mom on October 16, 2014, 09:37:18 PM
Quote from: Faust on October 16, 2014, 03:46:14 PM
Quote from: Your Mom on October 16, 2014, 12:43:29 AM
...that your skin has odor receptors?

Your whole body is a nose.

You're welcome.

How does this work, are their functions related to perspiration, heat detection etc?

They work the same way as the ones in our noses do (detecting and recognizing odor molecules) but rather than routing that information through the thalamus for conscious recognition, they seem to serve a regulatory function, responding to certain odors by triggering biochemical cascades that regulate how our cells transcribe DNA to produce certain proteins. For example, for reasons no one understands, exposing the skin to the odor of sandalwood triggers a cascade that results in more rapid healing of wounds.
Rapid healing? I'm guessing that is caused by free radicals.
Title: Re: So did you know
Post by: Mesozoic Mister Nigel on October 16, 2014, 11:12:43 PM
Quote from: Ragret on October 16, 2014, 10:33:01 PM
Quote from: Your Mom on October 16, 2014, 09:37:18 PM
Quote from: Faust on October 16, 2014, 03:46:14 PM
Quote from: Your Mom on October 16, 2014, 12:43:29 AM
...that your skin has odor receptors?

Your whole body is a nose.

You're welcome.

How does this work, are their functions related to perspiration, heat detection etc?

They work the same way as the ones in our noses do (detecting and recognizing odor molecules) but rather than routing that information through the thalamus for conscious recognition, they seem to serve a regulatory function, responding to certain odors by triggering biochemical cascades that regulate how our cells transcribe DNA to produce certain proteins. For example, for reasons no one understands, exposing the skin to the odor of sandalwood triggers a cascade that results in more rapid healing of wounds.
Rapid healing? I'm guessing that is caused by free radicals.

Is joke? I don't get it. :?
Title: Re: So did you know
Post by: Mesozoic Mister Nigel on October 16, 2014, 11:14:38 PM
Quote from: trix on October 16, 2014, 09:43:25 PM
lol I wonder if I could hold my nose and still detect the scent of something strong and easily recognizable.
I want to try this experiment!

You probably could, but more likely due to sneaky odor molecules sneaking into your nasal chamber, not due to the olfactory receptors in your skin, because they do not route to the odor-recognizing part of your brain.
Title: Re: So did you know
Post by: hooplala on October 16, 2014, 11:26:17 PM
Quote from: Your Mom on October 16, 2014, 11:14:38 PM
Quote from: trix on October 16, 2014, 09:43:25 PM
lol I wonder if I could hold my nose and still detect the scent of something strong and easily recognizable.
I want to try this experiment!

You probably could, but more likely due to sneaky odor molecules sneaking into your nasal chamber, not due to the olfactory receptors in your skin, because they do not route to the odor-recognizing part of your brain.

So, do they have any point, or are they like the appendix?
Title: Re: So did you know
Post by: Sita on October 17, 2014, 12:23:07 AM
Does this explain why I can taste smells?
Title: Re: So did you know
Post by: Eater of Clowns on October 17, 2014, 12:35:32 AM
Quote from: Sita on October 17, 2014, 12:23:07 AM
Does this explain why I can taste smells?

No, that's a stroke.
Title: Re: So did you know
Post by: Doktor Howl on October 17, 2014, 01:15:23 AM
Quote from: Eater of Clowns on October 17, 2014, 12:35:32 AM
Quote from: Sita on October 17, 2014, 12:23:07 AM
Does this explain why I can taste smells?

No, that's a stroke.

And LSD.  The drug that makes your music taste awful. 

Not that I would know personally, of course. 
Title: Re: So did you know
Post by: trix on October 17, 2014, 02:04:09 AM
hah, that's interesting though, I wonder if this ability could be put to some sort of use...
Title: Re: So did you know
Post by: LMNO on October 17, 2014, 02:50:35 AM
Ah. So, same receptors, different destination.
Title: Re: So did you know
Post by: Mesozoic Mister Nigel on October 17, 2014, 04:03:44 AM
Quote from: Hoopla on October 16, 2014, 11:26:17 PM
Quote from: Your Mom on October 16, 2014, 11:14:38 PM
Quote from: trix on October 16, 2014, 09:43:25 PM
lol I wonder if I could hold my nose and still detect the scent of something strong and easily recognizable.
I want to try this experiment!

You probably could, but more likely due to sneaky odor molecules sneaking into your nasal chamber, not due to the olfactory receptors in your skin, because they do not route to the odor-recognizing part of your brain.

So, do they have any point, or are they like the appendix?

Well, they trigger biochemical responses to environmental cues, so it seems a safe bet to say that they have a point, even if we don't really fully understand what's going on yet.
Title: Re: So did you know
Post by: Mesozoic Mister Nigel on October 17, 2014, 04:04:40 AM
Quote from: Sita on October 17, 2014, 12:23:07 AM
Does this explain why I can taste smells?

No, that's probably due to the fact that much of flavor is actually olfactory.
Title: Re: So did you know
Post by: Faust on October 17, 2014, 06:30:03 AM
That's really cool, So how much sensitivity are we talking here?

Discrete impulses that adjust our reflexes or being able to tell coke from pepsi blindfolded while passing a hand over them.
Title: Re: So did you know
Post by: Dildo Argentino on October 17, 2014, 06:36:41 AM
I wonder if this has anything to do with it... back when I worked as a pool attendant I got more than a fair share of truly revolting smells in large quantities (like the time I spent two days with a bunch of other guys using hydrochloric acid in chem-suits with rebreather apparatus to clean off half an inch of human fat from the inside of our pool - just the one example). And I had noticed that some atrocious smells have the added quality of not only not wanting to breathe while they are there, but also getting an icky feeling all over, a sense of touching something really vile. Rotting liver (I had the good fortune in a pharma factory) and badly rotten green peppers do that, for instance.
Title: Re: So did you know
Post by: Junkenstein on October 17, 2014, 10:17:25 AM
Quote from: Your Mom on October 16, 2014, 09:37:18 PM
Quote from: Faust on October 16, 2014, 03:46:14 PM
Quote from: Your Mom on October 16, 2014, 12:43:29 AM
...that your skin has odor receptors?

Your whole body is a nose.

You're welcome.

How does this work, are their functions related to perspiration, heat detection etc?

They work the same way as the ones in our noses do (detecting and recognizing odor molecules) but rather than routing that information through the thalamus for conscious recognition, they seem to serve a regulatory function, responding to certain odors by triggering biochemical cascades that regulate how our cells transcribe DNA to produce certain proteins. For example, for reasons no one understands, exposing the skin to the odor of sandalwood triggers a cascade that results in more rapid healing of wounds.

Wait, what? So Aromatherapy might not just be a giant pile of horseshit? What?
Title: Re: So did you know
Post by: Reginald Ret on October 17, 2014, 04:48:24 PM
Quote from: Hoopla on October 16, 2014, 11:26:17 PM
Quote from: Your Mom on October 16, 2014, 11:14:38 PM
Quote from: trix on October 16, 2014, 09:43:25 PM
lol I wonder if I could hold my nose and still detect the scent of something strong and easily recognizable.
I want to try this experiment!

You probably could, but more likely due to sneaky odor molecules sneaking into your nasal chamber, not due to the olfactory receptors in your skin, because they do not route to the odor-recognizing part of your brain.

So, do they have any point, or are they like the appendix?
rub pepper on elbow. it should work, I never tried it though.

Quote from: Your Mom on October 16, 2014, 11:12:43 PM
Quote from: Ragret on October 16, 2014, 10:33:01 PM
Quote from: Your Mom on October 16, 2014, 09:37:18 PM
Quote from: Faust on October 16, 2014, 03:46:14 PM
Quote from: Your Mom on October 16, 2014, 12:43:29 AM
...that your skin has odor receptors?

Your whole body is a nose.

You're welcome.

How does this work, are their functions related to perspiration, heat detection etc?

They work the same way as the ones in our noses do (detecting and recognizing odor molecules) but rather than routing that information through the thalamus for conscious recognition, they seem to serve a regulatory function, responding to certain odors by triggering biochemical cascades that regulate how our cells transcribe DNA to produce certain proteins. For example, for reasons no one understands, exposing the skin to the odor of sandalwood triggers a cascade that results in more rapid healing of wounds.
Rapid healing? I'm guessing that is caused by free radicals.

Is joke? I don't get it. :?
Naw, I just read somewhere that too much antioxidants slow wound healing and I concocted this whole explanation in my head in which both apoptosis and excessive cellular growth (cancer) are caused by free radicals, and both are needed for tissue regeneration therefore free radicals must promote tissue regeneration.

Uhm, I'm not sure if i've explained that right.
Let me try again in an logical-positivist-ish style:
1. Anti-oxidants reduce the presence of free radicals.
2. Extreme concentrations of anti-oxidants are thought to slow tissue regeneration.
3. Extreme concentrations of free radicals are thought to cause apoptosis and excessive cellular growth.
  3.1. Free radicals could be a positive factor in tissue regeneration.
END of logical positivist-ish style.

Isn't sandalwood slightly poisonous? That could cause a release of free-radicals.

I'm just idly theorizing here but the concept has it's attractions.
Title: Re: So did you know
Post by: Mesozoic Mister Nigel on October 18, 2014, 01:20:28 AM
Quote from: Faust on October 17, 2014, 06:30:03 AM
That's really cool, So how much sensitivity are we talking here?

Discrete impulses that adjust our reflexes or being able to tell coke from pepsi blindfolded while passing a hand over them.

More like reactions that regulate the expression of signaling that tells the cells to do certain things, like telling skin cells to multiply and migrate.
Title: Re: So did you know
Post by: Mesozoic Mister Nigel on October 18, 2014, 01:28:36 AM
Quote from: Ragret on October 17, 2014, 04:48:24 PM
Quote from: Hoopla on October 16, 2014, 11:26:17 PM
Quote from: Your Mom on October 16, 2014, 11:14:38 PM
Quote from: trix on October 16, 2014, 09:43:25 PM
lol I wonder if I could hold my nose and still detect the scent of something strong and easily recognizable.
I want to try this experiment!

You probably could, but more likely due to sneaky odor molecules sneaking into your nasal chamber, not due to the olfactory receptors in your skin, because they do not route to the odor-recognizing part of your brain.

So, do they have any point, or are they like the appendix?
rub pepper on elbow. it should work, I never tried it though.

Quote from: Your Mom on October 16, 2014, 11:12:43 PM
Quote from: Ragret on October 16, 2014, 10:33:01 PM
Quote from: Your Mom on October 16, 2014, 09:37:18 PM
Quote from: Faust on October 16, 2014, 03:46:14 PM
Quote from: Your Mom on October 16, 2014, 12:43:29 AM
...that your skin has odor receptors?

Your whole body is a nose.

You're welcome.

How does this work, are their functions related to perspiration, heat detection etc?

They work the same way as the ones in our noses do (detecting and recognizing odor molecules) but rather than routing that information through the thalamus for conscious recognition, they seem to serve a regulatory function, responding to certain odors by triggering biochemical cascades that regulate how our cells transcribe DNA to produce certain proteins. For example, for reasons no one understands, exposing the skin to the odor of sandalwood triggers a cascade that results in more rapid healing of wounds.
Rapid healing? I'm guessing that is caused by free radicals.

Is joke? I don't get it. :?
Naw, I just read somewhere that too much antioxidants slow wound healing and I concocted this whole explanation in my head in which both apoptosis and excessive cellular growth (cancer) are caused by free radicals, and both are needed for tissue regeneration therefore free radicals must promote tissue regeneration.

Uhm, I'm not sure if i've explained that right.
Let me try again in an logical-positivist-ish style:
1. Anti-oxidants reduce the presence of free radicals.
2. Extreme concentrations of anti-oxidants are thought to slow tissue regeneration.
3. Extreme concentrations of free radicals are thought to cause apoptosis and excessive cellular growth.
  3.1. Free radicals could be a positive factor in tissue regeneration.
END of logical positivist-ish style.

Isn't sandalwood slightly poisonous? That could cause a release of free-radicals.

I'm just idly theorizing here but the concept has it's attractions.

So you're thinking that the cell signaling triggered by sandalwood could be telling the mitochondria to bump up production of free radicals to age cells and tell them to divide more rapidly, speeding skin cell proliferation and migration? I don't know that much about it but I don't see why not. I mean, shorthand for all that would probably just be "metabolize faster".
Title: Re: So did you know
Post by: Dildo Argentino on October 18, 2014, 05:15:32 AM
Quote from: Junkenstein on October 17, 2014, 10:17:25 AM
Wait, what? So Aromatherapy might not just be a giant pile of horseshit? What?

I like that question!
Title: Re: So did you know
Post by: Mesozoic Mister Nigel on October 18, 2014, 06:33:43 AM
Quote from: Dodo Argentino on October 18, 2014, 05:15:32 AM
Quote from: Junkenstein on October 17, 2014, 10:17:25 AM
Wait, what? So Aromatherapy might not just be a giant pile of horseshit? What?

I like that question!

Unlike homeopathy, aromatherapy has some quite substantial evidence that it has effects.
Title: Re: So did you know
Post by: Junkenstein on October 18, 2014, 06:59:22 AM
The more you know.

I would have lost money on that.