Hmm.
See, I'd heard it was the other way 'round.
http://www.sciencedaily.com/releases/2013/03/130305145145.htm
So the fat would come first, then the inflammation.
However...
http://www.nytimes.com/2013/03/28/health/studies-focus-on-gut-bacteria-in-weight-loss.html?_r=0
Here the researchers first did gastric bypasses on mice, then took fecal bacteria from said mice and installed said bacteria in mice that had not received a bypass. The latter dropped weight.
Also mentioned in the Times article:
Edit: Though correlation ain't causation-so no telling here whether the fat or the bacteria came first, yeah...
http://www.livescience.com/39445-gut-bacteria-transplant-weight.html
Another mouse study:
...And in the second part of the same study:
BUUUT...
*Shrug*
Thanks for making me work my brain, BTW. It seems to be intent on turning into a pile of depressed goo these days.
See, I'd heard it was the other way 'round.
http://www.sciencedaily.com/releases/2013/03/130305145145.htm
QuoteMar. 5, 2013 — The inflammation of fat tissue is part of a spiraling series of events that leads to the development of type 2 diabetes in some obese people. But researchers have not understood what triggers the inflammation, or why.
In Cell Metabolism this month (cover), scientists from The Methodist Hospital report fat cells themselves are at least partly to blame -- high calorie diets cause the cells to make major histocompatibility complex II, a group of proteins usually expressed to help the immune system fight off viruses and bacteria.In overweight mice and humans the fat cells, or adipocytes, are issuing false distress signals -- they are not under attack by pathogens. But this still sends local immune cells into a tizzy, and that causes inflammation.
So the fat would come first, then the inflammation.
However...
http://www.nytimes.com/2013/03/28/health/studies-focus-on-gut-bacteria-in-weight-loss.html?_r=0
Here the researchers first did gastric bypasses on mice, then took fecal bacteria from said mice and installed said bacteria in mice that had not received a bypass. The latter dropped weight.
Also mentioned in the Times article:
QuoteA second study by a different group found that overweight people may be more likely to harbor a certain type of intestinal microbe...
The study involved 792 people who had their breath analyzed to help diagnose digestive orders. They agreed to let researchers measure the levels of hydrogen and methane; elevated levels indicate the presence of a microbe called Methanobrevibacter smithii. The people with the highest readings on the breath test were more likely to be heavier and have more body fat, and the researchers suspect that the microbes may be at least partly responsible for their obesity.
Edit: Though correlation ain't causation-so no telling here whether the fat or the bacteria came first, yeah...
http://www.livescience.com/39445-gut-bacteria-transplant-weight.html
Another mouse study:
Quotemice that had been raised in a sterile environment, so that they lacked gut bacteria, were transplanted with gut bacteria from either a lean person or an obese person. The researchers used gut bacteria from pairs of human twins, one of whom was lean and one who was obese.
Mice that received bacteria from an obese twin gained more weight and fat than those that received bacteria from a lean twin
...And in the second part of the same study:
Quote... the researchers put the mice together – they housed mice that received gut bacteria from a lean person along with mice that received bacteria from an obese person.
About 10 days later, mice with the "obese" bacteria underwent changes in metabolism that protect against obesity.
BUUUT...
Quotewhen the researchers repeated their housing experiment, but fed the mice a Westernized diet (high in fat and low in fiber) instead of their usual diet, the obesity protection was no longer transferred.
*Shrug*
Thanks for making me work my brain, BTW. It seems to be intent on turning into a pile of depressed goo these days.

