OPEN BAR: Top 10 things millenials hate about OB that we didn't know last week!

[Reginald Ret]

  This is dumber than homeopathy.
Wait:
first hit on a reputable source, namely pubmed: "Histamine intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation. Histamine is a biogenic amine that occurs to various degrees in many foods. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity."

Wait some more:
more than 500 hits on google scholar not counting citations and patents.
First one from 1983.

True, it is not a lot, but it seems to be taken seriously by people who are very good at the biochem techno-babble.

Example:

Histamine can be metabolized by two pathways:
- oxidative deamination via diamino oxidase (DAO) (formerly known as histaminease)
- ring methylation via histamine-N-methyl transferase (HNMT)

DAO is a secretory protein responsible for the breakdown of extra cellular histamine,
whereas HNMT, a cytosolic protein, inactivates histamine only intracellularly, for example
in the liver (2). The enzyme DAO therefore plays a key role in the breakdown of dietary
histamine. Insufficient DAO activity can thus lead to the symptoms described, e.g., after
ingestion of histamine rich foods, (5), alcohol (6) or histamine liberating or DAO blocking
medications (7).
Various possible mechanisms have been discussed as the cause of histamine intolerance
(1). The production of DAO may for example be reduced by damage to enterocytes in
gastrointestinal disease (11, 21). Other biogenic amines, alcohol (18) and medications
(7, 19) can also competitively inhibit the breakdown of histamine by DAO. Acquired
histamine intolerance may be reversible where the cause if removed, such as the dis-
continuation of DAO blocking medications.

Note: minor editing in quote because copypasta didn't work properly.

[Cain]

My boss is truly amazing. After 4 months of no staff meetings (which are required twice per term...we've had one all year) he has finally relented after numerous emails...and set a meeting date for when all four senior houseparents and myself are on holiday.

He has also, after six months of asking, finally put me and my co-worker in for first aid training.  First given date is the day after three nights on shift for me, and while she is on holiday.  The second is while she is still on holiday, and while I am doing day shift cover work, which I signed up to about 4 months ago.

[LMNO]

That's some solidly aggressive assbaggery right there.

[Cain]

Either that, or he really is that stupid.  I mean, he is emailing HR at the moment because he doesn't seem to grasp the concept that I have half a day of holiday owed to me.  It's like he cannot grasp that a half day holiday is possible and is convinced it's some kind of error.

[Mesozoic Mister Nigel]

This is dumber than homeopathy.
Wait:
first hit on a reputable source, namely pubmed: "Histamine intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation. Histamine is a biogenic amine that occurs to various degrees in many foods. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity."

Wait some more:
more than 500 hits on google scholar not counting citations and patents.
First one from 1983.

True, it is not a lot, but it seems to be taken seriously by people who are very good at the biochem techno-babble.

Example:

Histamine can be metabolized by two pathways:
- oxidative deamination via diamino oxidase (DAO) (formerly known as histaminease)
- ring methylation via histamine-N-methyl transferase (HNMT)

DAO is a secretory protein responsible for the breakdown of extra cellular histamine,
whereas HNMT, a cytosolic protein, inactivates histamine only intracellularly, for example
in the liver (2). The enzyme DAO therefore plays a key role in the breakdown of dietary
histamine. Insufficient DAO activity can thus lead to the symptoms described, e.g., after
ingestion of histamine rich foods, (5), alcohol (6) or histamine liberating or DAO blocking
medications (7).
Various possible mechanisms have been discussed as the cause of histamine intolerance
(1). The production of DAO may for example be reduced by damage to enterocytes in
gastrointestinal disease (11, 21). Other biogenic amines, alcohol (18) and medications
(7, 19) can also competitively inhibit the breakdown of histamine by DAO. Acquired
histamine intolerance may be reversible where the cause if removed, such as the dis-
continuation of DAO blocking medications.

Note: minor editing in quote because copypasta didn't work properly.

Yes, deficiencies in breaking down histamine is a real, biological occurrence. Just like deficiencies in breaking down gluten and deficiencies in breaking down lactose. That means there's just enough science behind a very rare enzyme pathway deficiency to make the health quack crowd BILLIONS when they convince millions of Americans that they, too, have a histamine intolerance.

[Doktor Howl]

Ah, the glamor of having something mildly debilitating.   

[Mesozoic Mister Nigel]

Portland: Today someone said "I know people who can't do bone broth because they have histamine intolerance".

Alone amongst the crowd, I am utterly unshocked by this.

Full of hate, but unshocked.

Betcha that 99% of these "histamine intolerant" people drink wine. Because the histamines in wine don't count.

[Doktor Howl]

Well, because reasons, it seems that I am now retired from the company.

Which is to say, I am getting my retirement benefits now (a huge fucking sum, in late August), instead of in 9 years. 

[Cain]

Portland: Today someone said "I know people who can't do bone broth because they have histamine intolerance".

Alone amongst the crowd, I am utterly unshocked by this.

Full of hate, but unshocked.

Betcha that 99% of these "histamine intolerant" people drink wine. Because the histamines in wine don't count.

Wine is calorie, carb, sugar, completely chemical-free goodness.  Everyone knows that.

Only red wine though.

[Mesozoic Mister Nigel]

Well, because reasons, it seems that I am now retired from the company.

Which is to say, I am getting my retirement benefits now (a huge fucking sum, in late August), instead of in 9 years.

Whoa! That's VERY interesting. And congratulations!

[Mesozoic Mister Nigel]

Portland: Today someone said "I know people who can't do bone broth because they have histamine intolerance".

Alone amongst the crowd, I am utterly unshocked by this.

Full of hate, but unshocked.

Betcha that 99% of these "histamine intolerant" people drink wine. Because the histamines in wine don't count.

Wine is calorie, carb, sugar, completely chemical-free goodness.  Everyone knows that.

Only red wine though.

[Q. G. Pennyworth]

Well, because reasons, it seems that I am now retired from the company.

Which is to say, I am getting my retirement benefits now (a huge fucking sum, in late August), instead of in 9 years.

Looking forward to however much of the story you can tell.

[hooplala]

Well, because reasons, it seems that I am now retired from the company.

Which is to say, I am getting my retirement benefits now (a huge fucking sum, in late August), instead of in 9 years.

One step closer to "get offa my damn lawn, you rotten kids,".

[Cain]

In other exciting news, a student of mine has lost his passport.  He only flies back to China tomorrow.

[Doktor Howl]

Portland: Today someone said "I know people who can't do bone broth because they have histamine intolerance".

Alone amongst the crowd, I am utterly unshocked by this.

Full of hate, but unshocked.

Betcha that 99% of these "histamine intolerant" people drink wine. Because the histamines in wine don't count.

Wine is calorie, carb, sugar, completely chemical-free goodness.  Everyone knows that.

Only red wine though.

And only brands that nobody's ever heard of, that you have to order special.