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I'll just leave this here....

Started by AFK, October 07, 2011, 03:34:21 PM

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East Coast Hustle

:lulz:

Good job finding the one context in which atropine actually has a synergistic effect with the medicine (atropine apparently acts as an anti-secretion agent which makes it useful in anti-diarrhea medicine).

but how about painkillers? I don't think anyone is trying to abuse anti-diarrhea drugs to get high.
Rabid Colostomy Hole Jammer of the Coming Apocalypse™

The Devil is in the details; God is in the nuance.


Some yahoo yelled at me, saying 'GIVE ME LIBERTY OR GIVE ME DEATH', and I thought, "I'm feeling generous today.  Why not BOTH?"

AFK

Quote from: Fuck You One-Eye on November 07, 2011, 01:26:15 PM
Maybe we should start with the medicines containing atropine that don't have "atropine" in the name?

Like codeine?

Just a thought.

ETA: looks like you beat me to it.

Uhh, Lomotil doesn't have atropine anywhere in its name.  I'm not sure what you are talking about.  And the atropine is there to deter addiction and over-dosage.  Isn't that what we've been talking about this entire time?  Why not start with a known while we look for the unknown?  
Cynicism is a blank check for failure.

AFK

Quote from: Fuck You One-Eye on November 07, 2011, 01:30:21 PM
:lulz:

Good job finding the one context in which atropine actually has a synergistic effect with the medicine (atropine apparently acts as an anti-secretion agent which makes it useful in anti-diarrhea medicine).

but how about painkillers? I don't think anyone is trying to abuse anti-diarrhea drugs to get high.

But atropine is a poison, right?  I mean, if it's a poison, it shouldn't be in drugs at all, right? 
Cynicism is a blank check for failure.

AFK

Ahh, here we go:

Belladonna and Opium Suppositories.

This fits all of the criteria:

It is for pain relief
It doesn't have atropine in the name
AND it contains atropine.

It is manufactured by Wyeth Ayerst which is now a part of Pfizer, and I posted a link earlier to get their contact information. 

Have at it and let us know what you discover!
Cynicism is a blank check for failure.

East Coast Hustle

The name of the medicine (as opposed to Lomotil which is the trade name) contains the words "atropine sulphate". Regardless, I sent them an inquiry. Their website is pretty borked and I can't say I appreciated having to give them my telephone number. And they make it pretty clear that I shouldn't expect an actual reply to my inquiry, but if I don't get a reply in a week or so I'll try sending them an actual physical letter.

Are you telling me that "Belladonna and Opium Suppositories" is the trade name of the medicine in question?
Rabid Colostomy Hole Jammer of the Coming Apocalypse™

The Devil is in the details; God is in the nuance.


Some yahoo yelled at me, saying 'GIVE ME LIBERTY OR GIVE ME DEATH', and I thought, "I'm feeling generous today.  Why not BOTH?"

AFK

Cynicism is a blank check for failure.

East Coast Hustle

Quote from: Everything's RWHN'd on November 07, 2011, 01:31:33 PM
Quote from: Fuck You One-Eye on November 07, 2011, 01:30:21 PM
:lulz:

Good job finding the one context in which atropine actually has a synergistic effect with the medicine (atropine apparently acts as an anti-secretion agent which makes it useful in anti-diarrhea medicine).

but how about painkillers? I don't think anyone is trying to abuse anti-diarrhea drugs to get high.

But atropine is a poison, right?  I mean, if it's a poison, it shouldn't be in drugs at all, right?  

DERP.

As you undoubtedly know, atropine is considered a core drug by the WHO. It is incredibly useful in certain contexts and for certain conditions. Painkillers/pain management is not one of those contexts. I don't think anyone ITT said that atropine had no medical value, only that it had no business being added to painkillers.
Rabid Colostomy Hole Jammer of the Coming Apocalypse™

The Devil is in the details; God is in the nuance.


Some yahoo yelled at me, saying 'GIVE ME LIBERTY OR GIVE ME DEATH', and I thought, "I'm feeling generous today.  Why not BOTH?"

East Coast Hustle

Quote from: Everything's RWHN'd on November 07, 2011, 01:46:32 PM
http://www.ic-network.com/glossary/glossarypain.html#Bell



Patient monograph information link on their site is no longer on their site. :lulz:

ETA: nor is the link on the Pfizer site available. Now I'm pretty sure you're just fucking with me.
Rabid Colostomy Hole Jammer of the Coming Apocalypse™

The Devil is in the details; God is in the nuance.


Some yahoo yelled at me, saying 'GIVE ME LIBERTY OR GIVE ME DEATH', and I thought, "I'm feeling generous today.  Why not BOTH?"

AFK

Quote from: Fuck You One-Eye on November 07, 2011, 01:46:56 PM
Quote from: Everything's RWHN'd on November 07, 2011, 01:31:33 PM
Quote from: Fuck You One-Eye on November 07, 2011, 01:30:21 PM
:lulz:

Good job finding the one context in which atropine actually has a synergistic effect with the medicine (atropine apparently acts as an anti-secretion agent which makes it useful in anti-diarrhea medicine).

but how about painkillers? I don't think anyone is trying to abuse anti-diarrhea drugs to get high.

But atropine is a poison, right?  I mean, if it's a poison, it shouldn't be in drugs at all, right?  

DERP.

As you undoubtedly know, atropine is considered a core drug by the WHO. It is incredibly useful in certain contexts and for certain conditions. Painkillers/pain management is not one of those contexts. I don't think anyone ITT said that atropine had no medical value, only that it had no business being added to painkillers.

No, it was very clearly labeled a "poison" by a couple of different posters in this thread.  I've been constantly drilled on this question of whether or not I agree with "adding a poison"....The "poison" in question being atropine.  And in one of the recent examples I just posted, Lomotil, it is specifically there to inhibit addiction.  You guys have been putting this forward to me as a very black and white question.  

But as you now point out, atropine indeed isn't always a poison and does have some benefits when added to medicines, including a benefit, in the case of Lomotil, of inhibiting over-dosage and addiction.  

This is precisely why I haven't answered the question the way you guys wanted me to answer the question because the premise was faulty as you've just demonstrated.  
Cynicism is a blank check for failure.

The Good Reverend Roger

I provided a fucking link, RWHN.  As I expected, you didn't even look at it.

Fuck this shit.
" It's just that Depeche Mode were a bunch of optimistic loveburgers."
- TGRR, shaming himself forever, 7/8/2017

"Billy, when I say that ethics is our number one priority and safety is also our number one priority, you should take that to mean exactly what I said. Also quality. That's our number one priority as well. Don't look at me that way, you're in the corporate world now and this is how it works."
- TGRR, raising the bar at work.

East Coast Hustle

A search of the entire Pfizer site returns no hits for any medicines called "belladonna & opium suppositories" or for "B & O Suprettes" (which is supposedly the trade name) or indeed for any medicines at all containing the words "belladonna" or "suprettes".
Rabid Colostomy Hole Jammer of the Coming Apocalypse™

The Devil is in the details; God is in the nuance.


Some yahoo yelled at me, saying 'GIVE ME LIBERTY OR GIVE ME DEATH', and I thought, "I'm feeling generous today.  Why not BOTH?"

East Coast Hustle

Quote from: Everything's RWHN'd on November 07, 2011, 01:52:06 PM
Quote from: Fuck You One-Eye on November 07, 2011, 01:46:56 PM
Quote from: Everything's RWHN'd on November 07, 2011, 01:31:33 PM
Quote from: Fuck You One-Eye on November 07, 2011, 01:30:21 PM
:lulz:

Good job finding the one context in which atropine actually has a synergistic effect with the medicine (atropine apparently acts as an anti-secretion agent which makes it useful in anti-diarrhea medicine).

but how about painkillers? I don't think anyone is trying to abuse anti-diarrhea drugs to get high.

But atropine is a poison, right?  I mean, if it's a poison, it shouldn't be in drugs at all, right? 

DERP.

As you undoubtedly know, atropine is considered a core drug by the WHO. It is incredibly useful in certain contexts and for certain conditions. Painkillers/pain management is not one of those contexts. I don't think anyone ITT said that atropine had no medical value, only that it had no business being added to painkillers.

No, it was very clearly labeled a "poison" by a couple of different posters in this thread.  I've been constantly drilled on this question of whether or not I agree with "adding a poison"....The "poison" in question being atropine.  And in one of the recent examples I just posted, Lomotil, it is specifically there to inhibit addiction.  You guys have been putting this forward to me as a very black and white question. 

But as you now point out, atropine indeed isn't always a poison and does have some benefits when added to medicines, including a benefit, in the case of Lomotil, of inhibiting over-dosage and addiction. 

This is precisely why I haven't answered the question the way you guys wanted me to answer the question because the premise was faulty as you've just demonstrated. 

Are you high?

There is no mention at all of it being added to lomotil to prevent abuse or addiction, which makes sense since people don't tend to get high on anti-diarrheal drugs. It's added to lomotil for its anti-secretion properties.

Rabid Colostomy Hole Jammer of the Coming Apocalypse™

The Devil is in the details; God is in the nuance.


Some yahoo yelled at me, saying 'GIVE ME LIBERTY OR GIVE ME DEATH', and I thought, "I'm feeling generous today.  Why not BOTH?"

AFK

Quote from: Fuck You One-Eye on November 07, 2011, 01:48:50 PM
Quote from: Everything's RWHN'd on November 07, 2011, 01:46:32 PM
http://www.ic-network.com/glossary/glossarypain.html#Bell



Patient monograph information link on their site is no longer on their site. :lulz:

ETA: nor is the link on the Pfizer site available. Now I'm pretty sure you're just fucking with me.

It is also manufactured by Paddock Labs:  http://www.paddocklabs.com/  

Do a search for belladonna and see what comes up.  The page seems to be borked but you can see the listing.

Or do you think that I somehow used some magickal HTML ju-jitsu to conjure that up?  
Cynicism is a blank check for failure.

East Coast Hustle

You really don't know very much at all about a subject that's critically important to the field you supposedly work in. Until you tell me where you got your degree and what degree you got, I'm calling bullshit.

Especially since, IIRC, you mentioned once a few years ago that you went to school for urban planning.

:troll:
Rabid Colostomy Hole Jammer of the Coming Apocalypse™

The Devil is in the details; God is in the nuance.


Some yahoo yelled at me, saying 'GIVE ME LIBERTY OR GIVE ME DEATH', and I thought, "I'm feeling generous today.  Why not BOTH?"

AFK

Quote from: Fuck You One-Eye on November 07, 2011, 01:55:24 PM
Quote from: Everything's RWHN'd on November 07, 2011, 01:52:06 PM
Quote from: Fuck You One-Eye on November 07, 2011, 01:46:56 PM
Quote from: Everything's RWHN'd on November 07, 2011, 01:31:33 PM
Quote from: Fuck You One-Eye on November 07, 2011, 01:30:21 PM
:lulz:

Good job finding the one context in which atropine actually has a synergistic effect with the medicine (atropine apparently acts as an anti-secretion agent which makes it useful in anti-diarrhea medicine).

but how about painkillers? I don't think anyone is trying to abuse anti-diarrhea drugs to get high.

But atropine is a poison, right?  I mean, if it's a poison, it shouldn't be in drugs at all, right? 

DERP.

As you undoubtedly know, atropine is considered a core drug by the WHO. It is incredibly useful in certain contexts and for certain conditions. Painkillers/pain management is not one of those contexts. I don't think anyone ITT said that atropine had no medical value, only that it had no business being added to painkillers.

No, it was very clearly labeled a "poison" by a couple of different posters in this thread.  I've been constantly drilled on this question of whether or not I agree with "adding a poison"....The "poison" in question being atropine.  And in one of the recent examples I just posted, Lomotil, it is specifically there to inhibit addiction.  You guys have been putting this forward to me as a very black and white question. 

But as you now point out, atropine indeed isn't always a poison and does have some benefits when added to medicines, including a benefit, in the case of Lomotil, of inhibiting over-dosage and addiction. 

This is precisely why I haven't answered the question the way you guys wanted me to answer the question because the premise was faulty as you've just demonstrated. 

Are you high?

There is no mention at all of it being added to lomotil to prevent abuse or addiction, which makes sense since people don't tend to get high on anti-diarrheal drugs. It's added to lomotil for its anti-secretion properties.

http://en.wikipedia.org/wiki/Diphenoxylate

QuoteAs with other medicinal opioids, iatrogenic addiction is uncommon although physical dependence secondary to treatment of a functional bowel disorder with diphenoxylate for more than 45–90 days may very well occur; it typically requires the use of high doses to impart a morbid seek orientation for the drug in the user. Because of this, diphenoxylate is manufactured and marketed as a combination drug with atropine (Lomotil, Pfizer) as an abuse deterrent. Lomotil was used during the Apollo program, as was pethidine.[1][2]

Cynicism is a blank check for failure.