Author Topic: Open Bar: Drinks are on the Supreme Court  (Read 36058 times)

Mesozoic Mister Nigel

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Re: Open Bar: Drinks are on the Supreme Court
« Reply #690 on: May 18, 2019, 01:56:30 am »
Hey spags.

I can't weigh in on Game of Thrones, because I quit watching it, but hey.

Hey! How have things been?

Pretty brilliant until last week, actually. I got a Masters degree in neurobiology and stuff. Now I'm in an epidemiology program learning to be John Snow.
Im guessing it was January 2007, a meeting in Bethesda, we got a bag of bees and just started smashing them on the desk, Charles Wick said. It was very complicated.


nullified

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Re: Open Bar: Drinks are on the Supreme Court
« Reply #691 on: May 18, 2019, 03:24:07 am »
Thats awesome! Im glad to hear its been good for you, and its good seeing you around here again.

Doktor Howl

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Re: Open Bar: Drinks are on the Supreme Court
« Reply #692 on: May 18, 2019, 03:58:02 am »
Yeah, break out the finest meats and cheeses, that kinda shit.
I met a traveller from an antique land
Who said: Two vast and trunkless legs of stone
Stand in the desert. Near them, on the sand,
Half sunk, shattered underpance lies,
With blown elastic, and exploded back,
Tell that its sculptor well those passions read
Which yet survive, stamped on these lifeless things,
The hand that mocked them and the heart that fed:
And on the pedestal these words appear:
"My name is Doktor Howl, Spag of Spags:
Look on my ass, ye Mighty, and despair!"
Nothing beside remains. Round the decay
Of that colossal wreck, boundless and bare
The lone and level sands stretch far away.

Doktor Howl

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Re: Open Bar: Drinks are on the Supreme Court
« Reply #693 on: May 18, 2019, 04:27:57 am »
Went to the gym for the first time since my back injury last year.

I am sore, but it's good to be somewhat active again.

I met a traveller from an antique land
Who said: Two vast and trunkless legs of stone
Stand in the desert. Near them, on the sand,
Half sunk, shattered underpance lies,
With blown elastic, and exploded back,
Tell that its sculptor well those passions read
Which yet survive, stamped on these lifeless things,
The hand that mocked them and the heart that fed:
And on the pedestal these words appear:
"My name is Doktor Howl, Spag of Spags:
Look on my ass, ye Mighty, and despair!"
Nothing beside remains. Round the decay
Of that colossal wreck, boundless and bare
The lone and level sands stretch far away.

Mesozoic Mister Nigel

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Re: Open Bar: Drinks are on the Supreme Court
« Reply #694 on: May 18, 2019, 07:48:11 am »
Thats awesome! Im glad to hear its been good for you, and its good seeing you around here again.

Thanks! I've gotten really interested in epigenetics and the social determinants of health, and particularly on the effects of early-life stress on later-life health. I'm especially into housing insecurity stress, and also, right now, kind of obsessed with how circadian disruption affects health. My MS thesis was on a circadian-derived reproductive process, which really got me hooked on circadian research. We have created an artificial year-round 16/8 photoperiod for ourselves, which is so different from our evolutionary photoperiod that I feel, given  the strong influence of photoperiod on metabolism and reproduction, can't help but have disruptive effects, like imagine it was midsummer in Copenhagen. What is your body going to think it's time to do? It's gonna be all oh, shit, winter is coming! And this effect should be worse the more extreme our human-made photoperiod is. It's especially concerning that most Americans get only 6-7 hours sleep a night, and our indoor lighting has transitioned from mostly medium and long-wave to a lot of short-wave and full spectrum light, because that's the kind of light our brains use to determine how long the days are.
Im guessing it was January 2007, a meeting in Bethesda, we got a bag of bees and just started smashing them on the desk, Charles Wick said. It was very complicated.


The Wizard Joseph

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Re: Open Bar: Drinks are on the Supreme Court
« Reply #695 on: May 18, 2019, 07:56:54 am »
Well hello again Nigel! Welcome back to PD.  :)





Went to the gym for the first time since my back injury last year.

I am sore, but it's good to be somewhat active again.



Glad to hear that you're on the mend. I didn't know you'd hurt your back. I've been taking atrocious amounts of Naproxen getting used to the job I'm doing. I highly recommended for muscle aches of all kinds. It's also an anti-inflammatory. But if you drink on it your insides will melt or something.
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 - Harry Potter and the Methods of Rationality :lulz:

nullified

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Re: Open Bar: Drinks are on the Supreme Court
« Reply #696 on: May 18, 2019, 08:02:36 am »
wow. Thats a lot of really interesting stuff that is weirdly relevant to me! (I could probably be a damned case study in your epigenetics thing, and maybe unrelatedly???my sleep cycle is so broken that I just last night double-dosed on sedatives and only slept two hours despite desperately aiming for 7+.)

Anywhere youre putting any of this out, or is it more of a general research (as opposed to scientific or academic) or saving for publication sorta deal right now? Id love to read more about it all, as I said, its almost creepily relevant to my life.

Fujikoma

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Re: Open Bar: Drinks are on the Supreme Court
« Reply #697 on: May 18, 2019, 12:47:57 pm »
Hey, Nigel, awesome! If you ever want to talk to someone with severe social deficiencies, assloads of developmental stress as well as a tendency to go nocturnal, pm me.

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Re: Open Bar: Drinks are on the Supreme Court
« Reply #698 on: May 18, 2019, 02:14:00 pm »
Thanks! I've gotten really interested in epigenetics and the social determinants of health, and particularly on the effects of early-life stress on later-life health. I'm especially into housing insecurity stress, and also, right now, kind of obsessed with how circadian disruption affects health. My MS thesis was on a circadian-derived reproductive process, which really got me hooked on circadian research. We have created an artificial year-round 16/8 photoperiod for ourselves, which is so different from our evolutionary photoperiod that I feel, given  the strong influence of photoperiod on metabolism and reproduction, can't help but have disruptive effects, like imagine it was midsummer in Copenhagen. What is your body going to think it's time to do? It's gonna be all oh, shit, winter is coming! And this effect should be worse the more extreme our human-made photoperiod is. It's especially concerning that most Americans get only 6-7 hours sleep a night, and our indoor lighting has transitioned from mostly medium and long-wave to a lot of short-wave and full spectrum light, because that's the kind of light our brains use to determine how long the days are.

I took last week off work to attend gardening horticulture classes at the local university, and one day I partook of a tour of the agriculture greenhouses.

At one point, the tour guide was showing off a greenhouse equipped with shades, and recounted how a researcher was having trouble getting a particular set of plants to flower, until she noted that the plants originated from Ecuador.  So, they used the shades to produce a 50% day/night cycle, and the plants began flowering.  (These greenhouses are above 52 N.  Equal length days and nights aren't something we do here).

It would be interesting if individual (human) reactions to photoperiod was partially dependent on geographic origin.  After all, lighter skin colour appears to be an adaptation to the amount of sunlight.
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Mesozoic Mister Nigel

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Re: Open Bar: Drinks are on the Supreme Court
« Reply #699 on: May 18, 2019, 03:15:33 pm »
Well hello again Nigel! Welcome back to PD.  :)

Thanks!

wow. Thats a lot of really interesting stuff that is weirdly relevant to me! (I could probably be a damned case study in your epigenetics thing, and maybe unrelatedly???my sleep cycle is so broken that I just last night double-dosed on sedatives and only slept two hours despite desperately aiming for 7+.)

Anywhere youre putting any of this out, or is it more of a general research (as opposed to scientific or academic) or saving for publication sorta deal right now? Id love to read more about it all, as I said, its almost creepily relevant to my life.

My first incredibly boring paper on circadian-relevant hormonal pathways will be published as a collaboration sometime next year, but since I just transitioned from basic research to epidemiology last Fall, it's gonna be a while before any of my current work is published. In the meantime, this paper may be of interest to you (let me know if you're unable to access it and I'll see if I can find a version that isn't behind a paywall, it's not always clear whether it's paywalled or not on my end): https://www.ncbi.nlm.nih.gov/pubmed/31026301

Hey, Nigel, awesome! If you ever want to talk to someone with severe social deficiencies, assloads of developmental stress as well as a tendency to go nocturnal, pm me.

Sounds like a laugh riot!

Seriously though, one of the reasons I'm so interested in this topic is that these issues you are experiencing are pervasive and increasing in our society. We tend to assume that health is driven by behavior, and it's just that in my behavioral neuroendocrinology training I started to see things the other way around. 

I took last week off work to attend gardening horticulture classes at the local university, and one day I partook of a tour of the agriculture greenhouses.

At one point, the tour guide was showing off a greenhouse equipped with shades, and recounted how a researcher was having trouble getting a particular set of plants to flower, until she noted that the plants originated from Ecuador.  So, they used the shades to produce a 50% day/night cycle, and the plants began flowering.  (These greenhouses are above 52 N.  Equal length days and nights aren't something we do here).

It would be interesting if individual (human) reactions to photoperiod was partially dependent on geographic origin.  After all, lighter skin colour appears to be an adaptation to the amount of sunlight.

That is a very interesting question, and I wouldn't be surprised if that is true. After all, circadian clock programming is determined partially through DNA methylation, and differential DNA methylation may occur during pregnancy, priming the fetus' wake-sleep rhythms to match the mother's. Interestingly, the time of day you are born matters; night babies are at higher risk for bipolar disorder and schizophrenia than day babies, and there is evidence of circadian disruption in both those diseases.

One thing to keep in mind is that there is nowhere on earth a 16/8 photoperiod occurs naturally year-round.
Im guessing it was January 2007, a meeting in Bethesda, we got a bag of bees and just started smashing them on the desk, Charles Wick said. It was very complicated.


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Re: Open Bar: Drinks are on the Supreme Court
« Reply #700 on: May 18, 2019, 04:52:43 pm »
Nine dicks in a dickboat?





Doktor Howl

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Re: Open Bar: Drinks are on the Supreme Court
« Reply #701 on: May 18, 2019, 06:27:12 pm »
All we need now is Hugh or Eldora back and it will be a proper PD party.   :kingmeh:
I met a traveller from an antique land
Who said: Two vast and trunkless legs of stone
Stand in the desert. Near them, on the sand,
Half sunk, shattered underpance lies,
With blown elastic, and exploded back,
Tell that its sculptor well those passions read
Which yet survive, stamped on these lifeless things,
The hand that mocked them and the heart that fed:
And on the pedestal these words appear:
"My name is Doktor Howl, Spag of Spags:
Look on my ass, ye Mighty, and despair!"
Nothing beside remains. Round the decay
Of that colossal wreck, boundless and bare
The lone and level sands stretch far away.

Fujikoma

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Re: Open Bar: Drinks are on the Supreme Court
« Reply #702 on: May 19, 2019, 04:10:17 pm »
I'm honestly glad all this horrible shit happened to me so I can have a fresh pair of eyes. Doktor Howl, did you try out Armageddon?

Doktor Howl

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Re: Open Bar: Drinks are on the Supreme Court
« Reply #703 on: May 20, 2019, 06:40:37 am »
I'm honestly glad all this horrible shit happened to me so I can have a fresh pair of eyes. Doktor Howl, did you try out Armageddon?

Not yet.  I landed a consulting gig and the spare time I have has been used dragging teabilly Christian sharia law freaks around by the ankles.

It's stressful as hell, I hate independent work, so in case it does me in, I have decided to have my will tattooed on my torso. Given how long probate takes, and the need for a physical copy of the will, this means my relatives will have to freeze my body for the duration, and wheel my frozen carcass into a conference room or courthouse 3 times every two months or so. At some point during each proceeding, my naked hairy frozen arse will have to be flung on the table and stared at.

Call it Dok's Last Fuck You.
I met a traveller from an antique land
Who said: Two vast and trunkless legs of stone
Stand in the desert. Near them, on the sand,
Half sunk, shattered underpance lies,
With blown elastic, and exploded back,
Tell that its sculptor well those passions read
Which yet survive, stamped on these lifeless things,
The hand that mocked them and the heart that fed:
And on the pedestal these words appear:
"My name is Doktor Howl, Spag of Spags:
Look on my ass, ye Mighty, and despair!"
Nothing beside remains. Round the decay
Of that colossal wreck, boundless and bare
The lone and level sands stretch far away.

Fujikoma

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Re: Open Bar: Drinks are on the Supreme Court
« Reply #704 on: May 20, 2019, 01:42:40 pm »
LOL. Well hopefully you get time someday... congrats on the job, though it sounds like it sucks.